The role and activity of SWI/SNF chromatin remodelers
T Bieluszewski, S Prakash, T Roulé… - Annual Review of Plant …, 2023 - annualreviews.org
SWITCH deficient SUCROSE NONFERMENTING (SWI/SNF) class chromatin remodeling
complexes (CRCs) use the energy derived from ATP hydrolysis to facilitate access of …
complexes (CRCs) use the energy derived from ATP hydrolysis to facilitate access of …
3D chromatin architecture and transcription regulation in cancer
Chromatin has distinct three-dimensional (3D) architectures important in key biological
processes, such as cell cycle, replication, differentiation, and transcription regulation. In turn …
processes, such as cell cycle, replication, differentiation, and transcription regulation. In turn …
Transcriptional coupling of distant regulatory genes in living embryos
The prevailing view of metazoan gene regulation is that individual genes are independently
regulated by their own dedicated sets of transcriptional enhancers. Past studies have …
regulated by their own dedicated sets of transcriptional enhancers. Past studies have …
[HTML][HTML] Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis
Summary N 6-methyladenosine (m 6 A) methylation is co-transcriptionally deposited on
mRNA, but a possible role of m 6 A on transcription remains poorly understood. Here, we …
mRNA, but a possible role of m 6 A on transcription remains poorly understood. Here, we …
[HTML][HTML] Histone modifications regulate pioneer transcription factor cooperativity
Pioneer transcription factors have the ability to access DNA in compacted chromatin.
Multiple transcription factors can bind together to a regulatory element in a cooperative way …
Multiple transcription factors can bind together to a regulatory element in a cooperative way …
Chromatin accessibility in the Drosophila embryo is determined by transcription factor pioneering and enhancer activation
KJ Brennan, M Weilert, S Krueger, A Pampari, H Liu… - Developmental cell, 2023 - cell.com
Chromatin accessibility is integral to the process by which transcription factors (TFs) read out
cis-regulatory DNA sequences, but it is difficult to differentiate between TFs that drive …
cis-regulatory DNA sequences, but it is difficult to differentiate between TFs that drive …
Kinetic principles underlying pioneer function of GAGA transcription factor in live cells
How pioneer factors interface with chromatin to promote accessibility for transcription control
is poorly understood in vivo. Here, we directly visualize chromatin association by the …
is poorly understood in vivo. Here, we directly visualize chromatin association by the …
GAF is essential for zygotic genome activation and chromatin accessibility in the early Drosophila embryo
MM Gaskill, TJ Gibson, ED Larson, MM Harrison - Elife, 2021 - elifesciences.org
Following fertilization, the genomes of the germ cells are reprogrammed to form the
totipotent embryo. Pioneer transcription factors are essential for remodeling the chromatin …
totipotent embryo. Pioneer transcription factors are essential for remodeling the chromatin …
Structures and consequences of pioneer factor binding to nucleosomes
E Luzete-Monteiro, KS Zaret - Current opinion in structural biology, 2022 - Elsevier
Pioneer transcription factors are able to bind a partially exposed motif on the surface of a
nucleosome, enabling the proteins to target sites in silent regions of chromatin that have …
nucleosome, enabling the proteins to target sites in silent regions of chromatin that have …
The control of transcriptional memory by stable mitotic bookmarking
M Bellec, J Dufourt, G Hunt, H Lenden-Hasse… - Nature …, 2022 - nature.com
To maintain cellular identities during development, gene expression profiles must be
faithfully propagated through cell generations. The reestablishment of gene expression …
faithfully propagated through cell generations. The reestablishment of gene expression …