Rationale. The developmental history and application of the 5-choice serial reaction time
task (5CSRTT) for measuring effects of drugs and other manipulations on attentional …

Deep-brain stimulation (DBS) of the subthalamic nucleus (STN) is an established treatment
for motor complications in Parkinson's disease. 20 years of experience with this procedure …

One of the defining characteristics of the research of Ann E. Kelley was her recognition that
the neuroscience underlying basic learning and motivation processes also shed significant …

The stop-signal reaction-time (SSRT) task measures inhibition of a response that has
already been initiated, that is, the ability to stop. Human subjects classified as “impulsive,” for …

Background The nucleus accumbens is the ventral extent of the striatum, the main input
nucleus of the basal ganglia. Recent hypotheses propose that the accumbens and its …

Many common psychiatric conditions, such as attention deficit/hyperactivity disorder
(ADHD), obsessive-compulsive disorder (OCD), Parkinson's disease, addiction and …

Behavioural abnormalities such as impulse control disorders may develop when patients
with Parkinson's disease receive dopaminergic therapy, although they can be controlled by …

Pathological gambling (PG) related to dopaminergic treatment in Parkinson's disease (PD)
is part of a spectrum of behavioral disorders called the dopamine dysregulation syndrome …

Over the last decades, extensive basic and clinical knowledge has been acquired on the
use of subthalamic nucleus (STN) deep brain stimulation (DBS) for Parkinson's disease …

Deep brain stimulation (DBS) is a reversible technique that is currently used for the
treatment of Parkinson disease and may be suitable for the treatment of psychiatric …