The immune response in the brain has been widely investigated and while many studies
have focused on the proinflammatory cytotoxic response, the brain's innate immune system …

Arginine has multiple metabolic fates and thus is one of the most versatile amino acids. Not
only is it metabolically interconvertible with the amino acids proline and glutamate, but it also …

ARGINASE: A CRITICAL REGULATOR OF NITRIC OXIDE SYNTHESIS AND VASCULAR
FUNCTION - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …

As arginine can serve as precursor to a wide range of compounds, including nitric oxide,
creatine, urea, polyamines, proline, glutamate and agmatine, there is considerable interest …

The transforming growth factor-β (TGF-β) signaling plays a critical role in the development
and tissue homeostasis in metazoans, and deregulation of TGF-β signaling leads to many …

Arginase, a binuclear manganese metalloenzyme in the urea, catalyzes the hydrolysis of L-
arginine to urea and L-ornithine. Both isoforms, arginase 1 and arginase 2 perform …

While transport processes for amino acids and glucose have long been known to be
expressed in the luminal and abluminal membranes of the endothelium comprising the …

Background—Lung inflammation precedes the development of hypoxia-induced pulmonary
hypertension (HPH); however, its role in the pathogenesis of HPH is poorly understood. We …

The supply of arginine may become rate limiting for enzymatic reactions that use this
semiessential amino acid as a substrate (eg, nitric oxide, agmatine, creatine, and urea …

Asymmetric (NG, NG) dimethylarginine (ADMA) is present in plasma and cells. It can inhibit
nitric oxide synthase (NOS) that generates nitric oxide (NO) and cationic amino acid …