This educational review will highlight the historical and contemporary references that
establish a basic understanding of measurements of kidney function in the neonate and its …

A deficit or loss in the number of nephrons, the functional unit of the kidney, can induce
compensatory growth and hyperfunction of remaining nephrons. An increase in single …

The current understanding of mammalian kidney development is largely based on mouse
models. Recent landmark studies revealed pervasive differences in renal embryogenesis …

Nephron number (N glom) and size (Vglom) are correlated with risk for chronic
cardiovascular and kidney disease and may be predictive of renal allograft viability …

It has been suggested that low nephron number contributes to glomerular hypertension and
hyperperfusion injury in progressive chronic kidney disease (CKD). The incidence of CKD in …

Background Nephron number can be estimated from glomerular density and cortical
volume. However, because of measurement biases, this approach needs refinement …

The kidney contains the functional units, the nephrons, surrounded by the renal interstitium.
Previously we discovered that, once Six2-expressing nephron progenitor cells and Foxd1 …

Studies of human nephron number have been conducted for well over a century and have
uncovered a large variability in nephron number. However, the mechanisms influencing …

Recent studies have reported that total nephron number varies widely in human kidneys and
some racial groups with low nephron number have a higher incidence of hypertension and …

Around 1/1000 people have a solitary kidney. Congenital conditions mainly include
multicystic dysplastic kidney and unilateral renal aplasia/agenesis; acquired conditions are …