A molecular understanding of high-density lipoprotein (HDL) will allow a more complete
grasp of its interactions with key plasma remodelling factors and with cell-surface proteins …

Mesenchymal stem cells (MSCs) are multipotent cells with a substantial potential in human
regenerative medicine due to their ability to migrate to sites of injury, capability to suppress …

The existence of extracellular phosphoproteins has been acknowledged for over a century.
However, research in this area has been undeveloped largely because the kinases that …

Protein phosphorylation is a fundamental mechanism regulating nearly every aspect of
cellular life. Several secreted proteins are phosphorylated, but the kinases responsible are …

The family with sequence similarity 20, member C (Fam20C) has recently been identified as
the Golgi casein kinase. Fam20C phosphorylates secreted proteins on Ser-x-Glu/pSer motifs …

Platelets play an essential role in maintaining homeostasis in the circulatory system after an
injury by forming a platelet thrombus, but they also occupy a central node in the …

Background. Vascular stiffening occurs in normal ageing and is accelerated in chronic
kidney disease (CKD). Vascular calcification contributes to this stiffening and to the high …

The formation of fetuin-A-containing calciprotein particles (CPP) may facilitate the clearance
of calcium phosphate nanocrystals from the extracellular fluid. These crystals may otherwise …

Large-scale mass spectrometry-based peptidomics for drug discovery is relatively
unexplored because of challenges in peptide degradation and identification following tissue …

Although numerous extracellular phosphoproteins have been identified, the protein kinases
within the secretory pathway have only recently been discovered, and their regulation is …