Hierarchical nanomaterials assembled from peptoids and other sequence-defined synthetic polymers

Z Li, B Cai, W Yang, CL Chen - Chemical Reviews, 2021 - ACS Publications
In nature, the self-assembly of sequence-specific biopolymers into hierarchical structures
plays an essential role in the construction of functional biomaterials. To develop synthetic …

A field guide to foldamers

DJ Hill, MJ Mio, RB Prince, TS Hughes… - Chemical …, 2001 - ACS Publications
The breadth of structure and function displayed by the molecules of biology is remarkable.
Considering that there are only three major biopolymer backbones (proteins, ribonucleic …

β-Peptides: from structure to function

RP Cheng, SH Gellman, WF DeGrado - Chemical reviews, 2001 - ACS Publications
In recent years, our understanding of protein structure and function has advanced rapidly,
providing a mechanistic understanding of a wide variety of biological processes. As an …

The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters

PA Wender, DJ Mitchell… - Proceedings of the …, 2000 - National Acad Sciences
Certain proteins contain subunits that enable their active translocation across the plasma
membrane into cells. In the specific case of HIV-1, this subunit is the basic domain Tat49–57 …

Peptoid polymers: a highly designable bioinspired material

J Sun, RN Zuckermann - ACS nano, 2013 - ACS Publications
Bioinspired polymeric materials are attracting increasing attention due to significant
advantages over their natural counterparts: the ability to precisely tune their structures over a …

Peptoids and polypeptoids at the frontier of supra-and macromolecular engineering

N Gangloff, J Ulbricht, T Lorson, H Schlaad… - Chemical …, 2016 - ACS Publications
In most general terms, polymers and their supramolecular assemblies have been defining
life on this planet since its conception. Polymers of nucleic acids carry the code of life and …

Dynamic combinatorial chemistry and virtual combinatorial libraries

JM Lehn - Essays in Contemporary Chemistry: From Molecular …, 2001 - Wiley Online Library
Dynamic Combinatorial Chemistry and Virtual Combinatorial Libraries<link href='#fn1'></link>
Page 1 Dynamic Combinatorial Chemistry and Virtual Combinatorial Libraries 1 ) by Jean-Marie …

GALA: a designed synthetic pH-responsive amphipathic peptide with applications in drug and gene delivery

W Li, F Nicol, FC Szoka Jr - Advanced drug delivery reviews, 2004 - Elsevier
GALA is a 30 amino acid synthetic peptide with a glutamic acid-alanine-leucine-alanine
(EALA) repeat that also contains a histidine and tryptophan residue as spectroscopic …

Recent progress in the design of monodisperse, sequence‐defined macromolecules

SC Solleder, RV Schneider, KS Wetzel… - Macromolecular …, 2017 - Wiley Online Library
This review describes different synthetic strategies towards sequence‐defined,
monodisperse macromolecules, which are built up by iterative approaches and lead to …

Free-floating ultrathin two-dimensional crystals from sequence-specific peptoid polymers

KT Nam, SA Shelby, PH Choi, AB Marciel, R Chen… - Nature materials, 2010 - nature.com
The design and synthesis of protein-like polymers is a fundamental challenge in materials
science. A biomimetic approach is to explore the impact of monomer sequence on non …