The gut microbiome is emerging as a key regulator of brain function and behavior and is
associated with symptoms of several neurological disorders. There is emerging evidence …

In addition to their traditional role as immune sentinels, recent discoveries over the last
decade have shown that microglial functions now include regulation of neuronal/glial cell …

Microglia are the resident immune cells of the center nervous system and participate in
various neurological diseases. Here we determined the function of microglia in …

Microglia are key players in maintaining brain homeostasis and exhibit phenotypic
alterations in response to epileptic stimuli. However, it is still relatively unknown if these …

Emerging from the depths of evolution, pituitary adenylate cyclase-activating polypeptide
(PACAP) and its receptors (ie, PAC1, VPAC1, VPAC2) are present in multicellular organisms …

Minocycline, a second-generation tetracycline antibiotic is being widely tested in animals as
well as clinical settings for the management of multiple neurological disorders. The drug has …

We evaluated whether pharmacologically targeting T-type Ca 2+ channels with Z944, a
potent and selective antagonist, has disease-modifying effects in a model of temporal lobe …

Objective Prolonged electroencephalographic (EEG) monitoring in chronic epilepsy rodent
models has become an important tool in preclinical drug development of new therapies, in …

Key points Rats subjected to sustained hypoxia (SH) present increases in arterial pressure
(AP) and in glutamatergic transmission in the nucleus tractus solitarius (NTS) neurons …

Targeting neuroinflammation is a novel frontier in the prevention and treatment of epilepsy.
A substantial body of evidence supports a key role for neuroinflammation in epileptogenesis …