Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were
originally thought to be intracellular signaling pathways that mediate cytokine signals in …

Mendelian susceptibility to mycobacterial disease (MSMD) is a rare condition characterized
by predisposition to clinical disease caused by weakly virulent mycobacteria, such as BCG …

Since their discovery in patients with autosomal dominant (AD) chronic mucocutaneous
candidiasis (CMC) in 2011, heterozygous STAT1 gain-of-function (GOF) mutations have …

The body is host to a wide variety of microbial communities from which the immune system
protects us and that are important for the normal development of the immune system and for …

Innate resistance to Candida albicans in mucosal tissues requires the production of
interleukin-17A (IL-17A) by tissue-resident cells early during infection, but the mechanism of …

The induction and action of type I interferon (IFN) is of fundamental importance in human
immune defenses toward microbial pathogens, particularly viruses. Basic discoveries within …

Heterozygous gain-of-function (GOF) mutations in STAT1 in patients with chronic
mucocutaneous candidiasis (CMC) and hypothyroidism were discovered in 2011. CMC is …

Given the" inborn" nature of the innate immune system, it is surprising to find that innate
immune function does in fact change with age. Similar patterns of distinct Toll-like-receptor …

Here we identified a population of bone marrow neutrophils that constitutively expressed the
transcription factor RORγt and produced and responded to interleukin 17A (IL-17A (IL-17)) …

The interaction between Candida albicans and its host cells is characterized by a complex
interplay between the expression of fungal virulence factors, which results in adherence …