[HTML][HTML] Alzheimer's disease pathophysiology in the retina
The retina is an emerging CNS target for potential noninvasive diagnosis and tracking of
Alzheimer's disease (AD). Studies have identified the pathological hallmarks of AD …
Alzheimer's disease (AD). Studies have identified the pathological hallmarks of AD …
Determinants of approved acetylcholinesterase inhibitor response outcomes in Alzheimer's disease: relevance for precision medicine in neurodegenerative diseases
Acetylcholinesterase inhibitors (ChEI) are the global standard of care for the symptomatic
treatment of Alzheimer's disease (AD) and show significant positive effects in …
treatment of Alzheimer's disease (AD) and show significant positive effects in …
Retinal pathological features and proteome signatures of Alzheimer's disease
Alzheimer's disease (AD) pathologies were discovered in the accessible neurosensory
retina. However, their exact nature and topographical distribution, particularly in the early …
retina. However, their exact nature and topographical distribution, particularly in the early …
Identification of retinal oligomeric, citrullinated, and other tau isoforms in early and advanced AD and relations to disease status
This study investigates various pathological tau isoforms in the retina of individuals with
early and advanced Alzheimer's disease (AD), exploring their connection with disease …
early and advanced Alzheimer's disease (AD), exploring their connection with disease …
Neuropathological hallmarks in the post-mortem retina of neurodegenerative diseases
FJ Hart de Ruyter, MJAP Evers, THJ Morrema… - Acta …, 2024 - Springer
The retina is increasingly recognised as a potential source of biomarkers for
neurodegenerative diseases. Hallmark protein aggregates in the retinal neuronal tissue …
neurodegenerative diseases. Hallmark protein aggregates in the retinal neuronal tissue …
Retina pathology as a target for biomarkers for Alzheimer's disease: Current status, ophthalmopathological background, challenges, and future directions
J Alber, F Bouwman, J den Haan… - Alzheimer's & …, 2024 - Wiley Online Library
There is emerging evidence that amyloid beta protein (Aβ) and tau‐related lesions in the
retina are associated with Alzheimer's disease (AD). Aβ and hyperphosphorylated (p)‐tau …
retina are associated with Alzheimer's disease (AD). Aβ and hyperphosphorylated (p)‐tau …
Retinal peri-arteriolar versus peri-venular amyloidosis, hippocampal atrophy, and cognitive impairment: exploratory trial
OM Dumitrascu, J Doustar, DT Fuchs… - Acta Neuropathologica …, 2024 - Springer
The relationship between amyloidosis and vasculature in cognitive impairment and
Alzheimer's disease (AD) pathogenesis is increasingly acknowledged. We conducted a …
Alzheimer's disease (AD) pathogenesis is increasingly acknowledged. We conducted a …
Label-free hyperspectral imaging and deep-learning prediction of retinal amyloid β-protein and phosphorylated tau
Alzheimer's disease (AD) is a major risk for the aging population. The pathological hallmarks
of AD—an abnormal deposition of amyloid β-protein (Aβ) and phosphorylated tau (pTau) …
of AD—an abnormal deposition of amyloid β-protein (Aβ) and phosphorylated tau (pTau) …
Artificial intelligence in ophthalmology: an insight into neurodegenerative disease
AD Patil, V Biousse, NJ Newman - Current Opinion in …, 2022 - journals.lww.com
In order to produce effective AI-DLS for the diagnosis and monitoring of neurodegenerative
disease, multicenter international collaboration is required to prospectively produce large …
disease, multicenter international collaboration is required to prospectively produce large …
[HTML][HTML] Color Fundus Photography and Deep Learning Applications in Alzheimer Disease
Objective To report the development and performance of 2 distinct deep learning models
trained exclusively on retinal color fundus photographs to classify Alzheimer disease (AD) …
trained exclusively on retinal color fundus photographs to classify Alzheimer disease (AD) …