Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives
Clinical and translational research has played a major role in advancing our understanding
of pulmonary hypertension (PH), including pulmonary arterial hypertension and other forms …
of pulmonary hypertension (PH), including pulmonary arterial hypertension and other forms …
[HTML][HTML] Human iPSC banking: barriers and opportunities
CY Huang, CL Liu, CY Ting, YT Chiu… - Journal of biomedical …, 2019 - Springer
The introduction of induced pluripotent stem cells (iPSCs) has opened up the potential for
personalized cell therapies and ushered in new opportunities for regenerative medicine …
personalized cell therapies and ushered in new opportunities for regenerative medicine …
Patient and disease–specific induced pluripotent stem cells for discovery of personalized cardiovascular drugs and therapeutics
Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …
PPARγ-p53-mediated vasculoregenerative program to reverse pulmonary hypertension
JK Hennigs, A Cao, CG Li, M Shi, J Mienert… - Circulation …, 2021 - Am Heart Assoc
Rationale: In pulmonary arterial hypertension (PAH), endothelial dysfunction and obliterative
vascular disease are associated with DNA damage and impaired signaling of BMPR2 (bone …
vascular disease are associated with DNA damage and impaired signaling of BMPR2 (bone …
Differentiation, evaluation, and application of human induced pluripotent stem cell–derived endothelial cells
The emergence of induced pluripotent stem cell (iPSC) technology paves the way to
generate large numbers of patient-specific endothelial cells (ECs) that can be potentially …
generate large numbers of patient-specific endothelial cells (ECs) that can be potentially …
[HTML][HTML] Remodeling of active endothelial enhancers is associated with aberrant gene-regulatory networks in pulmonary arterial hypertension
Environmental and epigenetic factors often play an important role in polygenic disorders.
However, how such factors affect disease-specific tissues at the molecular level remains to …
However, how such factors affect disease-specific tissues at the molecular level remains to …
[HTML][HTML] Intrinsic endocardial defects contribute to hypoplastic left heart syndrome
Hypoplastic left heart syndrome (HLHS) is a complex congenital heart disease characterized
by abnormalities in the left ventricle, associated valves, and ascending aorta. Studies have …
by abnormalities in the left ventricle, associated valves, and ascending aorta. Studies have …
[HTML][HTML] PPARγ interaction with UBR5/ATMIN promotes DNA repair to maintain endothelial homeostasis
CG Li, C Mahon, NM Sweeney, E Verschueren… - Cell reports, 2019 - cell.com
Using proteomic approaches, we uncovered a DNA damage response (DDR) function for
peroxisome proliferator activated receptor γ (PPARγ) through its interaction with the DNA …
peroxisome proliferator activated receptor γ (PPARγ) through its interaction with the DNA …
[HTML][HTML] RNA-binding proteins: Emerging therapeutics for vascular dysfunction
VA Cornelius, H Naderi-Meshkin, S Kelaini, A Margariti - Cells, 2022 - mdpi.com
Vascular diseases account for a significant number of deaths worldwide, with cardiovascular
diseases remaining the leading cause of mortality. This ongoing, ever-increasing burden …
diseases remaining the leading cause of mortality. This ongoing, ever-increasing burden …
Advanced in vitro lung models for drug and toxicity screening: the promising role of induced pluripotent stem cells
The substantial socioeconomic burden of lung diseases, recently highlighted by the
disastrous impact of the coronavirus disease 2019 (COVID‐19) pandemic, accentuates the …
disastrous impact of the coronavirus disease 2019 (COVID‐19) pandemic, accentuates the …