Inhibition and induction of CYP enzymes in humans: an update

J Hakkola, J Hukkanen, M Turpeinen, O Pelkonen - Archives of Toxicology, 2020 - Springer
The cytochrome P450 (CYP) enzyme family is the most important enzyme system catalyzing
the phase 1 metabolism of pharmaceuticals and other xenobiotics such as herbal remedies …

Interindividual differences in caffeine metabolism and factors driving caffeine consumption

A Nehlig - Pharmacological reviews, 2018 - ASPET
Most individuals adjust their caffeine intake according to the objective and subjective effects
induced by the methylxanthine. However, to reach the desired effects, the quantity of …

Neuroprotective effects of coffee bioactive compounds: a review

K Socała, A Szopa, A Serefko, E Poleszak… - International journal of …, 2020 - mdpi.com
Coffee is one of the most widely consumed beverages worldwide. It is usually identified as a
stimulant because of a high content of caffeine. However, caffeine is not the only coffee …

Safety aspects of the use of quercetin as a dietary supplement

S Andres, S Pevny, R Ziegenhagen… - Molecular nutrition & …, 2018 - Wiley Online Library
The flavonoid quercetin is frequently found in low amounts as a secondary plant metabolite
in fruits and vegetables. Isolated quercetin is also marketed as a dietary supplement, mostly …

Quercetin: A flavonol with multifaceted therapeutic applications?

G D'Andrea - Fitoterapia, 2015 - Elsevier
Great interest is currently centered on the biologic activities of quercetin a polyphenol
belonging to the class of flavonoids, natural products well known for their beneficial effects …

Polyphenols: From theory to practice

A Bertelli, M Biagi, M Corsini, G Baini, G Cappellucci… - Foods, 2021 - mdpi.com
Background: The importance of polyphenols in human health is well known; these
compounds are common in foods, such as fruits, vegetables, spices, extra virgin olive oil and …

Modulation of metabolic detoxification pathways using foods and food‐derived components: a scientific review with clinical application

RE Hodges, DM Minich - Journal of nutrition and metabolism, 2015 - Wiley Online Library
Research into human biotransformation and elimination systems continues to evolve.
Various clinical and in vivo studies have been undertaken to evaluate the effects of foods …

The flavonoid quercetin in disease prevention and therapy: facts and fancies

M Russo, C Spagnuolo, I Tedesco, S Bilotto… - Biochemical …, 2012 - Elsevier
Biochemical and genetic studies on cellular and animal models on the mechanism (s) of
action of phytochemicals provide a functional explanation of how and why a diet rich in fruits …

Quercetin.

GS Kelly - Alternative medicine review, 2011 - search.ebscohost.com
The article features quercetin, one of the subclasses of flavonoid compounds. The dietary
presence of quercetin is provided in foods and in the form of quercetin glycosides. Factors …

The role of quercetin, flavonols and flavones in modulating inflammatory cell function

S Chirumbolo - Inflammation & Allergy-Drug Targets (Formerly …, 2010 - ingentaconnect.com
Flavonoids are polyphenolic substances derived from plants that play several
pharmacological activities. They possess anti-viral, anti-microbial, anti-inflammatory and anti …