Here we review recent advances in understanding the regulation of mRNA synthesis in
Saccharomyces cerevisiae. Many fundamental gene regulatory mechanisms have been …

The transport of RNA molecules from the nucleus to the cytoplasm is fundamental for gene
expression. The different RNA species that are produced in the nucleus are exported …

Fungi produce an abundance of bioactive secondary metabolites which can be utilized as
antibiotics and pharmaceutical drugs. The genes encoding secondary metabolites are …

Nuclear pore complexes (NPCs) are vital to nuclear–cytoplasmic communication in
eukaryotes. The yeast NPC‐associated TREX‐2 complex, also known as the Thp1–Sac3 …

COMPASS, the yeast homolog of the mammalian MLL complex, is a histone H3 lysine 4
(H3K4) methylase consisting of Set1 (KMT2) and seven other polypeptides, including …

Extrachromosomal circular DNA (eccDNA) facilitates adaptive evolution by allowing rapid
and extensive gene copy number variation and is implicated in the pathology of cancer and …

Regulation of eukaryotic gene expression is far more complex than one might have
imagined 30 years ago. However, progress towards understanding gene regulatory …

Histone modifications play an important role in transcription. We previously studied histone
H2B ubiquitylation on lysine 123 and subsequent deubiquitylation by SAGA-associated …

Throughout the last decade, great advances have been made in our understanding of how
DNA-templated cellular processes occur in the native chromatin environment. Proteins that …

Targeting of a gene to the nuclear pore complexes (NPCs), known as gene gating, can affect
its transcriptional state,,,,,,,,. However, the mechanism underlying gene gating is poorly …