Systemic scleroderma (SSc) is one of the most complex systemic autoimmune diseases. It
targets the vasculature, connective tissue-producing cells (namely fibroblasts/myofibroblasts …

Systemic sclerosis (SSc) is a prototypical inflammatory fibrotic disease involving
inflammation, vascular abnormalities and fibrosis that primarily affect the skin and lungs. The …

Scleroderma refers to an autoimmune connective tissue fibrosing disease, including three
different subsets: localized scleroderma, limited cutaneous systemic sclerosis, and diffuse …

Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling
of the precapillary pulmonary arteries, with excessive proliferation of vascular cells. Although …

Connective tissue disease (CTD) related interstitial lung disease (CTD-ILD) is one of the
leading causes of morbidity and mortality of CTD. Clinically, CTD-ILD is highly heterogenous …

Systemic sclerosis (SSc) is a rare autoimmune disease characterized by fibroproliferative
alterations of the microvasculature leading to fibrosis and loss of function of the skin and …

Interstitial lung disease is a common pulmonary manifestation of connective tissue diseases
and results in significant morbidity and mortality. Although all connective tissue diseases are …

Objective To determine human leucocyte antigen-class II (HLA-class II)(DRB1, DQB1, DQA1
and DPB1) alleles, haplotypes and shared epitopes associated with scleroderma (systemic …

Autoimmune rheumatic diseases pose many problems that have, in general, already been
solved in the field of cancer. The heterogeneity of each disease, the clinical similarities and …

Systemic sclerosis (SSc) is a multisystem auto-immune disease. The two main subtypes of
SSc (limited and diffuse) typically have differing courses and prognoses. New classification …