Neutrophils as emerging therapeutic targets
Neutrophils are the most abundant circulating leukocytes, being the first line of defence
against bacterial and fungal infections. However, neutrophils also contribute to tissue …
against bacterial and fungal infections. However, neutrophils also contribute to tissue …
[HTML][HTML] DAMPs and NETs in sepsis
Sepsis is a deadly inflammatory syndrome caused by an exaggerated immune response to
infection. Much has been focused on host response to pathogens mediated through the …
infection. Much has been focused on host response to pathogens mediated through the …
[HTML][HTML] Neutrophil extracellular traps and extracellular histones potentiate IL-17 inflammation in periodontitis
Neutrophil infiltration is a hallmark of periodontitis, a prevalent oral inflammatory condition in
which Th17-driven mucosal inflammation leads to destruction of tooth-supporting bone …
which Th17-driven mucosal inflammation leads to destruction of tooth-supporting bone …
[HTML][HTML] Cell type-specific roles of NF-κB linking inflammation and thrombosis
M Mussbacher, M Salzmann, C Brostjan… - Frontiers in …, 2019 - frontiersin.org
The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …
[HTML][HTML] Neutrophil extracellular traps and their implications in cardiovascular and inflammatory disease
J Klopf, C Brostjan, W Eilenberg… - International journal of …, 2021 - mdpi.com
Neutrophils are primary effector cells of innate immunity and fight infection by phagocytosis
and degranulation. Activated neutrophils also release neutrophil extracellular traps (NETs) …
and degranulation. Activated neutrophils also release neutrophil extracellular traps (NETs) …
Neutrophil extracellular traps in atherosclerosis and atherothrombosis
Neutrophil extracellular traps expelled from suicidal neutrophils comprise a complex
structure of nuclear chromatin and proteins of nuclear, granular, and cytosolic origin. These …
structure of nuclear chromatin and proteins of nuclear, granular, and cytosolic origin. These …
[HTML][HTML] Platelets, thrombo-inflammation, and cancer: collaborating with the enemy
AL Palacios-Acedo, D Mège, L Crescence… - Frontiers in …, 2019 - frontiersin.org
Platelets are small anucleate cells present in the blood stream, their typical role in primary
hemostasis has been well-described. However, new evidence suggests that they have …
hemostasis has been well-described. However, new evidence suggests that they have …
Association of neutrophil activation, more than platelet activation, with thrombotic complications in coronavirus disease 2019
E Petito, E Falcinelli, U Paliani, E Cesari… - The Journal of …, 2021 - academic.oup.com
Background Severe acute respiratory syndrome coronavirus 2 infection is associated with
hypercoagulability, which predisposes to venous thromboembolism (VTE). We analyzed …
hypercoagulability, which predisposes to venous thromboembolism (VTE). We analyzed …
The pathophysiology of SARS-CoV-2: A suggested model and therapeutic approach
In this paper, a model is proposed of the pathophysiological processes of COVID-19 starting
from the infection of human type II alveolar epithelial cells (pneumocytes) by SARS-CoV-2 …
from the infection of human type II alveolar epithelial cells (pneumocytes) by SARS-CoV-2 …
Neutrophils and neutrophil extracellular traps in the liver and gastrointestinal system
Neutrophil extracellular traps (NETs) have an important role during infection by helping
neutrophils to capture and kill pathogens. However, evidence is accumulating that …
neutrophils to capture and kill pathogens. However, evidence is accumulating that …