Background The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the
endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence …

The a 28-amino acid peptide ghrelin was discovered in 1999 as a growth hormone (GH)
releasing peptide. Soon after its discovery, ghrelin was found to increase body weight and …

Emerging evidence suggests that the intestinal microbiota is a source of sleep-promoting
signals. Bacterial metabolites and components of the bacterial cell wall are likely to provide …

Evidence for the role of sleep on metabolic and endocrine function has been reported more
than four decades ago. In the past 30 years, the prevalence of obesity and diabetes has …

Sleep is essential for health. Indeed, poor sleep is consistently linked to the development of
systemic disease, including depression, metabolic syndrome, and cognitive impairments …

Ghrelin, an orexigenic peptide synthesized by endocrine cells of the gastric mucosa, is
released in the bloodstream in response to a negative energetic status. Since discovery, the …

Ghrelin is a 28-amino-acid peptide hormone, first described in 1999 and broadly expressed
in the organism. As the only known orexigenic hormone secreted in the periphery, it …

abstract Context: The acylation of ghrelin is essential for its stimulatory effects on GH release
and appetite. Most of the physiology of ghrelin has been defined based on the assay of total …

Eating and sleeping represent two mutually exclusive behaviors that satisfy distinct
homeostatic needs. Because an animal cannot eat and sleep at the same time, brain …

Obestatin, a 23 amino acid peptide recently isolated from the rat stomach, is encoded by the
same gene that encodes ghrelin. With the use of an antiserum directed against the …