[HTML][HTML] XFELs for structure and dynamics in biology
JCH Spence - IUCrJ, 2017 - scripts.iucr.org
The development and application of the free-electron X-ray laser (XFEL) to structure and
dynamics in biology since its inception in 2009 are reviewed. The research opportunities …
dynamics in biology since its inception in 2009 are reviewed. The research opportunities …
Short-wavelength free-electron laser sources and science: a review
EA Seddon, JA Clarke, DJ Dunning… - Reports on Progress …, 2017 - iopscience.iop.org
This review is focused on free-electron lasers (FELs) in the hard to soft x-ray regime. The
aim is to provide newcomers to the area with insights into: the basic physics of FELs, the …
aim is to provide newcomers to the area with insights into: the basic physics of FELs, the …
Retinal isomerization in bacteriorhodopsin captured by a femtosecond x-ray laser
INTRODUCTION Retinal is a light-sensitive protein ligand that is used by all domains of life
to process the information and energy content of light. Retinal-binding proteins are integral …
to process the information and energy content of light. Retinal-binding proteins are integral …
A three-dimensional movie of structural changes in bacteriorhodopsin
Bacteriorhodopsin (bR) is a light-driven proton pump and a model membrane transport
protein. We used time-resolved serial femtosecond crystallography at an x-ray free electron …
protein. We used time-resolved serial femtosecond crystallography at an x-ray free electron …
Dynamics and mechanism of a light-driven chloride pump
Chloride transport by microbial rhodopsins is an essential process for which molecular
details such as the mechanisms that convert light energy to drive ion pumping and ensure …
details such as the mechanisms that convert light energy to drive ion pumping and ensure …
[HTML][HTML] Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons
Historically, room-temperature structure determination was succeeded by cryo-
crystallography to mitigate radiation damage. Here, we demonstrate that serial millisecond …
crystallography to mitigate radiation damage. Here, we demonstrate that serial millisecond …
Proton uptake mechanism in bacteriorhodopsin captured by serial synchrotron crystallography
Conformational dynamics are essential for proteins to function. We adapted time-resolved
serial crystallography developed at x-ray lasers to visualize protein motions using …
serial crystallography developed at x-ray lasers to visualize protein motions using …
[HTML][HTML] Ultrafast structural changes direct the first molecular events of vision
Vision is initiated by the rhodopsin family of light-sensitive G protein-coupled receptors
(GPCRs). A photon is absorbed by the 11-cis retinal chromophore of rhodopsin, which …
(GPCRs). A photon is absorbed by the 11-cis retinal chromophore of rhodopsin, which …
A bright future for serial femtosecond crystallography with XFELs
X-ray free electron lasers (XFELs) have the potential to revolutionize macromolecular
structural biology due to the unique combination of spatial coherence, extreme peak …
structural biology due to the unique combination of spatial coherence, extreme peak …
[PDF][PDF] Sample delivery for serial crystallography at free-electron lasers and synchrotrons
ML Grünbein, G Nass Kovacs - Acta Crystallographica Section D …, 2019 - journals.iucr.org
The high peak brilliance and femtosecond pulse duration of X-ray free-electron lasers
(XFELs) provide new scientific opportunities for experiments in physics, chemistry and …
(XFELs) provide new scientific opportunities for experiments in physics, chemistry and …