Calcific aortic stenosis (AS) is the most prevalent heart valve disorder in developed
countries. It is characterized by progressive fibro-calcific remodelling and thickening of the …

Calcific aortic valve disease (CAVD) is the most common disorder affecting heart valves and
is characterized by thickening, fibrosis and mineralization of the aortic valve leaflets …

Aortic-Valve Stenosis — From Patients at Risk to Severe Valve Obstruction | New England Journal
of Medicine Skip to main content Access provided by Charite - Universitaetsmedizin Berlin The …

Background Limited information is available regarding genetic contributions to valvular
calcification, which is an important precursor of clinical valve disease. Methods We …

Valvular heart disease remains common in industrialized countries, because the decrease
in prevalence of rheumatic heart diseases has been accompanied by an increase in that of …

With increased life expectancy and aging of the population, aortic stenosis is now one of the
most common valvular heart diseases. Early recognition and management of aortic stenosis …

Aims Although highly heritable, the genetic etiology of calcific aortic stenosis (AS) remains
incompletely understood. The aim of this study was to discover novel genetic contributors to …

Calcific aortic valve stenosis (CAVS) is a common and life-threatening heart disease and the
current treatment options cannot stop or delay its progression. A GWAS on 1009 cases and …

Recent genome-wide association and transcriptome-wide association studies have
identified an association between the PALMD locus, encoding palmdelphin, a protein …

Calcific aortic stenosis (AS) is the most common valve disease in the high-income countries
and is set to become a major health care burden with an aging population. 1 It is …