Cisplatin and other platinum-based chemotherapeutic drugs have been used extensively for
the treatment of human cancers such as bladder, blood, breast, cervical, esophageal, head …

Simple Summary In this review, the authors propose a crosswise examination of cytarabine-
related issues ranging from the spectrum of clinical activity and severe toxicities, through …

Importance With cure rates of childhood acute lymphoblastic leukemia (ALL) exceeding
85%, there is a need to mitigate treatment toxicities that can compromise quality of life …

In vitro human cell line models have been widely used for cancer pharmacogenomic studies
to predict clinical response, to help generate pharmacogenomic hypothesis for further …

Testicular cancer represents the most curable solid tumor, with a 10-year survival rate of
more than 95%. Given the young average age at diagnosis, it is estimated that effective …

A long-term goal of pharmacogenomics research is the design of individualized therapy
based on the genomic sequence of the patient, in order to maximize response and minimize …

The practice of Ayurveda, the traditional medicine of India, is based on the concept of three
major constitutional types (Vata, Pitta and Kapha) defined as “Prakriti”. To the best of our …

Breast cancer is a complex disease caused by the progressive accumulation of multiple
gene mutations combined with epigenetic dysregulation of critical genes and protein …

Lymphoblastoid cell lines (LCLs), originally collected as renewable sources of DNA, are
now being used as a model system to study genotype–phenotype relationships in human …

Population differences observed for complex traits may be attributed to the combined effect
of socioeconomic, environmental, genetic and epigenetic factors. To better understand …