Exploration of the detailed structure–activity relationships of isatin and their isomers as monoamine oxidase inhibitors
Monoamine oxidase (MAO) is a protein with a key function in the catabolism of neuroamines
in both central and peripheral parts of the body. MAO-A and-B are two isozymes of this …
in both central and peripheral parts of the body. MAO-A and-B are two isozymes of this …
A mathematical model analysis of meningitis with treatment and vaccination in fractional derivatives
In this paper, we develop a new mathematical model based on the Atangana Baleanu
Caputo (ABC) derivative to investigate meningitis dynamics. We explain why fractional …
Caputo (ABC) derivative to investigate meningitis dynamics. We explain why fractional …
Piperidine: A Versatile Heterocyclic Ring for Developing Monoamine Oxidase Inhibitors
J Jayan, N Chandran, AC Thekkantavida… - ACS …, 2023 - ACS Publications
The monoamine oxidase enzyme (MAO), which is bound on the membrane of mitochondria,
catalyzes the oxidative deamination of endogenous and exogenous monoamines, including …
catalyzes the oxidative deamination of endogenous and exogenous monoamines, including …
Quinazolinone-based benzenesulfonamides with low toxicity and high affinity as monoamine oxidase-A inhibitors: Synthesis, biological evaluation and induced-fit …
The research in selective monoamine oxidases (MAO-A and MAO-B) inhibitors has been
increased due to their therapeutic value for neurodegenerative diseases. In this study, 4-((2 …
increased due to their therapeutic value for neurodegenerative diseases. In this study, 4-((2 …
Design, Synthesis, and Biological Investigation of Quinazoline Derivatives as Multitargeting Therapeutics in Alzheimer's Disease Therapy
An efficient and promising method of treating complex neurodegenerative diseases like
Alzheimer's disease (AD) is the multitarget-directed approach. Here in this work, a series of …
Alzheimer's disease (AD) is the multitarget-directed approach. Here in this work, a series of …
Transition metal (II) complexes of halogenated derivatives of (E)-4-(2-(pyridin-2-ylmethylene) hydrazinyl) quinazoline: structure, antioxidant activity, DNA-binding DNA …
C Kakoulidou, CT Chasapis, AG Hatzidimitriou… - Dalton …, 2022 - pubs.rsc.org
Two novel halogenated (Br-and F-) quinazoline derivatives, namely [(E)-4-(2-((6-
bromopyridin-2-yl) methylene) hydrazinyl) quinazoline](L1) and [(E)-4-(2-((3-fluoropyridin-2 …
bromopyridin-2-yl) methylene) hydrazinyl) quinazoline](L1) and [(E)-4-(2-((3-fluoropyridin-2 …
Potential for Aedes aegypti Larval Control and Environmental Friendliness of the Compounds Containing 2-Methyl-3,4-dihydroquinazolin-4-one Heterocycle
2-Methylquinazolin-4 (3 H)-one was prepared by the reaction of anthranilic acid, acetic
anhydride, and ammonium acetate. The reaction of 2-methylquinazolin-4 (3 H)-one with N …
anhydride, and ammonium acetate. The reaction of 2-methylquinazolin-4 (3 H)-one with N …
Selected class of enamides bearing nitro functionality as dual-acting with highly selective monoamine oxidase-B and BACE1 inhibitors
A small series of nitro group-bearing enamides was designed, synthesized (NEA1–NEA5),
and evaluated for their inhibitory profiles of monoamine oxidases (MAOs) and β-site amyloid …
and evaluated for their inhibitory profiles of monoamine oxidases (MAOs) and β-site amyloid …
Greener Synthesis of Pyrroloquinazoline Derivatives: Recent Advances
NM Moreira, JRN dos Santos… - European Journal of …, 2022 - Wiley Online Library
Quinazoline derivatives draw attention from a synthetic and medicinal chemistry point of
view, given the wide range of biological activities already described. This class of fused N …
view, given the wide range of biological activities already described. This class of fused N …
Anticancer Potential of Quinazoline Derivatives Modified with Hydrazones and Triazoles Against MG‐63 Cancer Cell Line
R Kumar, A Kumar, R Kamal, A Kumar… - ChemistrySelect, 2024 - Wiley Online Library
Antiproliferative potential of quinazoline flanked bis‐hydrazones and quinazoline fused bis‐
triazoles against human bone cancer cell line (MG‐63) have been described in the present …
triazoles against human bone cancer cell line (MG‐63) have been described in the present …