α-Synuclein misfolding and aggregation: Implications in Parkinson's disease pathogenesis
Abstract α-Synuclein (α-Syn) has been extensively studied for its structural and biophysical
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …
Liquid-liquid phase separation of α-synuclein: a new mechanistic insight for α-synuclein aggregation associated with Parkinson's disease pathogenesis
Aberrant aggregation of the misfolded presynaptic protein, α-Synuclein (α-Syn) into Lewy
body (LB) and Lewy neuritis (LN) is a major pathological hallmark of Parkinson's disease …
body (LB) and Lewy neuritis (LN) is a major pathological hallmark of Parkinson's disease …
Structural and functional insights into α-synuclein fibril polymorphism
Abnormal accumulation of aggregated α-synuclein (α-Syn) is seen in a variety of
neurodegenerative diseases, including Parkinson's disease (PD), multiple system atrophy …
neurodegenerative diseases, including Parkinson's disease (PD), multiple system atrophy …
Protein misfolding and amyloid nucleation through liquid–liquid phase separation
Liquid–liquid phase separation (LLPS) is an emerging phenomenon in cell physiology and
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …
Intermediates of α-synuclein aggregation: Implications in Parkinson's disease pathogenesis
Cytoplasmic deposition of aberrantly misfolded α-synuclein (α-Syn) is a common feature of
synucleinopathies, including Parkinson's disease (PD). However, the precise pathogenic …
synucleinopathies, including Parkinson's disease (PD). However, the precise pathogenic …
Effects of α-synuclein-associated post-translational modifications in Parkinson's disease
S He, F Wang, KKL Yung, S Zhang… - ACS chemical …, 2021 - ACS Publications
α-Synuclein (α-syn), a small highly conserved presynaptic protein containing 140 amino
acids, is thought to be the main pathological hallmark in related neurodegenerative …
acids, is thought to be the main pathological hallmark in related neurodegenerative …
Distinct effects of familial Parkinson's disease-associated mutations on α-synuclein phase separation and amyloid aggregation
B Xu, F Fan, Y Liu, Y Liu, L Zhou, H Yu - Biomolecules, 2023 - mdpi.com
The Lewy bodies and Lewy neurites are key pathological hallmarks of Parkinson's disease
(PD). Single-point mutations associated with familial PD cause α-synuclein (α-Syn) …
(PD). Single-point mutations associated with familial PD cause α-synuclein (α-Syn) …
Cryo-EM structure of amyloid fibril formed by α-synuclein hereditary A53E mutation reveals a distinct protofilament interface
Synucleinopathies like Parkinson's disease (PD), dementia with Lewy bodies (DLB), and
multiple systems atrophy (MSA), have the same pathologic feature of misfolded α-synuclein …
multiple systems atrophy (MSA), have the same pathologic feature of misfolded α-synuclein …
Mechanisms of dopamine oxidation and Parkinson's disease
J Segura-Aguilar, I Paris - Handbook of neurotoxicity, 2022 - Springer
Dopamine's ability to oxidize to aminochrome explains why this molecule may be a
neurotoxic compound that induces toxicity in both cell lines and animal models …
neurotoxic compound that induces toxicity in both cell lines and animal models …
In silico analysis of alpha‐synuclein protein variants and posttranslational modifications related to Parkinson's disease
ANR da Silva, GRC Pereira, LFS Bonet… - Journal of Cellular …, 2024 - Wiley Online Library
Parkinson's disease (PD) is among the most prevalent neurodegenerative disorders,
affecting over 10 million people worldwide. The protein encoded by the SNCA gene, alpha …
affecting over 10 million people worldwide. The protein encoded by the SNCA gene, alpha …