Non-viral vectors for RNA delivery

Y Yan, XY Liu, A Lu, XY Wang, LX Jiang… - Journal of Controlled …, 2022 - Elsevier
RNA-based therapy is a promising and potential strategy for disease treatment by
introducing exogenous nucleic acids such as messenger RNA (mRNA), small interfering …

Cancer nanotechnology: current status and perspectives

JA Kemp, YJ Kwon - Nano convergence, 2021 - Springer
Modern medicine has been waging a war on cancer for nearly a century with no tangible
end in sight. Cancer treatments have significantly progressed, but the need to increase …

Ice inhibition for cryopreservation: materials, strategies, and challenges

T Chang, G Zhao - Advanced Science, 2021 - Wiley Online Library
Cryopreservation technology has developed into a fundamental and important supporting
method for biomedical applications such as cell‐based therapeutics, tissue engineering …

Current advance of nanotechnology in diagnosis and treatment for malignant tumors

B Wang, S Hu, Y Teng, J Chen, H Wang, Y Xu… - … and Targeted Therapy, 2024 - nature.com
Cancer remains a significant risk to human health. Nanomedicine is a new multidisciplinary
field that is garnering a lot of interest and investigation. Nanomedicine shows great potential …

Continuous inertial cavitation evokes massive ROS for reinforcing sonodynamic therapy and immunogenic cell death against breast carcinoma

Y Yin, X Jiang, L Sun, H Li, C Su, Y Zhang, G Xu, X Li… - Nano Today, 2021 - Elsevier
Intratumoral immunosuppressive microenvironment (ISM) remains the dominant limitation to
disable oncological immunotherapy such as immunogenic cell death (ICD). To resolve the …

The intracellular and extracellular microenvironment of tumor site: the trigger of stimuli‐responsive drug delivery systems

X Jing, H Hu, Y Sun, B Yu, H Cong, Y Shen - Small Methods, 2022 - Wiley Online Library
The tumor microenvironment (TME), including intracellular and extracellular
microenvironment, contains many biochemical indicators (such as acidity/alkalinity, oxygen …

Carboxylated chitosan-mediated improved efficacy of mesoporous silica nanoparticle-based targeted drug delivery system for breast cancer therapy

G Lohiya, DS Katti - Carbohydrate Polymers, 2022 - Elsevier
Nanoparticle-based targeting of overexpressed cell-surface receptors is a promising
strategy that provides precise delivery of drugs to cancer cells. In the present study, we …

Nanoparticle targeting of de novo profibrotic macrophages mitigates lung fibrosis

A Singh, S Chakraborty, SW Wong… - Proceedings of the …, 2022 - National Acad Sciences
The pathogenesis of lung fibrosis involves hyperactivation of innate and adaptive immune
pathways that release inflammatory cytokines and growth factors such as tumor growth …

Platelet membrane and stem cell exosome hybrids enhance cellular uptake and targeting to heart injury

S Hu, X Wang, Z Li, D Zhu, J Cores, Z Wang, J Li, X Mei… - Nano today, 2021 - Elsevier
Exosomes from mesenchymal stem cells have been widely studied as therapeutics to treat
myocardial infarction. However, exosomes injected for therapeutic purposes face a number …

Nanoparticles-based drug delivery and gene therapy for breast cancer: Recent advancements and future challenges

Z Mirza, S Karim - Seminars in cancer biology, 2021 - Elsevier
Breast cancer (BC) is amongst the most lethal cancer among females and conventional
treatment methods like surgery, radiotherapy and chemotherapy are not effective enough as …