Cell-free DNA (cfDNA) derived from tumours is present in the plasma of cancer patients. The
majority of currently available studies on the use of this circulating tumour DNA (ctDNA) deal …

Lung cancer is the deadliest cancer worldwide. Tissue biopsy is currently employed for the
diagnosis and molecular stratification of lung cancer. Liquid biopsy is a minimally invasive …

We review research regarding the epidemiology, risk factors, genetic susceptibility,
molecular pathology, and early detection of SCLC, a deadly tumor that accounts for 14% of …

The sex ratio is a key ecological demographic parameter crucial for population viability.
However, the epigenetic mechanisms operating during gonadal development regulating …

The lung microbiome plays an essential role in maintaining healthy lung function, including
host immune homeostasis. Lung microbial dysbiosis or disruption of the gut-lung axis can …

Inflammatory bowel disease (IBD) is a destructive, recurrent, and heterogeneous disease. Its
detailed pathogenesis is still unclear, although available evidence supports that IBD is …

Despite efforts to improve earlier diagnosis of non-small cell lung cancer (NSCLC), most
patients present with advanced stage disease, which is often associated with poor survival …

Aim Lung cancer screening reduces mortality. We aim to validate the performance of Lung
EpiCheck, a six-marker panel methylation-based plasma test, in the detection of lung cancer …

Background Detection of lung cancer at earlier stage can greatly improve patient survival.
We aim to develop, validate, and implement a cost-effective ctDNA-methylation-based …

Non-small cell lung cancer (NSCLC) is the most prevalent histological type of lung cancer
and the leading cause of death globally. Patients with NSCLC have a poor prognosis for …