Thirty years ago, a novel axis of the renin-angiotensin system (RAS) was unveiled by the
discovery of angiotensin-(1− 7)[ANG-(1− 7)] generation in vivo. Later, angiotensin …

Itch is a unique sensory experience that is encoded by genetically distinguishable neurons
both in the peripheral nervous system (PNS) and central nervous system (CNS) to elicit a …

Itch triggers scratching, a behavioural defence mechanism that aids in the removal of
harmful irritants and parasites. Chemical itch is triggered by many endogenous and …

More than twelve morphologically and physiologically distinct subtypes of primary
somatosensory neuron report salient features of our internal and external environments,,–. It …

Somatosensory neurons with cell bodies in the dorsal root ganglia (DRG) project to the skin,
muscles, bones, and viscera to detect touch and temperature as well as to mediate …

Joint pain is the defining symptom of osteoarthritis (OA) but its origin and mechanisms
remain unclear. Here, we investigated an unprecedented role of osteoclast-initiated …

The multimodal properties of the human somatosensory system continue to be unravelled.
There is mounting evidence that one of these submodalities—touch—has another …

Topological domains are key architectural building blocks of chromosomes, but their
functional importance and evolutionary dynamics are not well defined. We performed …

Mast cells (MCs), which are granulated tissue-resident cells of hematopoietic lineage,
contribute to vascular homeostasis, innate/adaptive immunity, and wound healing. However …

Sensory neurons are distinguished by distinct signaling networks and receptive
characteristics. Thus, sensory neuron types can be defined by linking transcriptome-based …