When type III interferon (IFN-λ; also known as interleukin-28 [IL-28] and IL-29) was
discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs …

Type III interferons (IFNs) or IFN-λs regulate a similar set of genes as type I IFNs, but
whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect …

Background The stability and propagation of hepatitis C virus (HCV) is dependent on a
functional interaction between the HCV genome and liver-expressed microRNA-122 (miR …

Hepatitis C virus has been identified a quarter of a decade ago as a leading cause of
chronic viral hepatitis that can lead to cirrhosis and hepatocellular carcinoma. Only a …

Chronic infection with hepatitis C virus (HCV) is a common cause of liver cirrhosis and
cancer. We performed RNA sequencing in primary human hepatocytes activated with …

Hepatitis C virus (HCV) is a global public health problem involving chronic infection of the
liver, which can cause liver disease and is linked with liver cancer. Viral innate immune …

Five human hepatitis viruses cause most of the acute and chronic liver disease worldwide.
Over the past 25 years, hepatitis C virus (HCV) in particular has received much interest …

Background and aims MicroRNA-122 (miR-122) is an important host factor for hepatitis C
virus (HCV) and promotes HCV RNA accumulation. Decreased intra-hepatic levels of miR …

Type I interferons (IFN) are cytokines that are rapidly secreted upon microbial infections and
regulate all aspects of the immune response. In humans 15 type I IFN subtypes exist, of …

Approximately 3% of the world population is chronically infected with the hepatitis C virus
(HCV), with potential development of cirrhosis and hepatocellular carcinoma. Despite the …