Background Medicinal cannabis has received increased research attention over recent
years due to loosening global regulatory changes. Medicinal cannabis has been reported to …

Schizophrenia is a devastating mental illness with a strong genetic component that is the
subject of extensive research. Despite the high heritability, it is well recognized that non …

There are at least two types of cannabinoid receptors (CB1 and CB2). Ligands activating
these G protein-coupled receptors (GPCRs) include the phytocannabinoid Δ9 …

Importance Prior studies have demonstrated reduced dendritic spine density in the
dorsolateral prefrontal cortex (DLPFC) in schizophrenia. However, it remains unclear how …

Although schizophrenia is an illness that has been historically characterized by the
presence of positive symptomatology, decades of research highlight the importance of …

Aims Estimate the prevalence of cannabis dependence and its contribution to the global
burden of disease. Methods Systematic reviews of epidemiological data on cannabis …

Heavy cannabis use has been frequently associated with increased rates of mental illness
and cognitive impairment, particularly amongst adolescent users. However, the …

The origins of schizophrenia have eluded clinicians and researchers since Kraepelin and
Bleuler began documenting their findings. However, large clinical research efforts in recent …

Human epidemiological studies have provided compelling evidence that the risk of
developing schizophrenia is significantly enhanced following prenatal and/or perinatal …

The neurodevelopmental hypothesis of schizophrenia has been highly influential in shaping
our current thinking about modeling the disease in animals. Based on the findings provided …