Molecular determinants of BK channel functional diversity and functioning

R Latorre, K Castillo… - Physiological …, 2017 - journals.physiology.org
Large-conductance Ca2+-and voltage-activated K+ (BK) channels play many physiological
roles ranging from the maintenance of smooth muscle tone to hearing and neurosecretion …

Ca2+-Activated K+ Channels: From Protein Complexes to Function

H Berkefeld, B Fakler, U Schulte - Physiological reviews, 2010 - journals.physiology.org
Molecular research on ion channels has demonstrated that many of these integral
membrane proteins associate with partner proteins, often versatile in their function, or even …

BK channel activation: structural and functional insights

US Lee, J Cui - Trends in neurosciences, 2010 - cell.com
The voltage-and Ca 2+-activated K+(BK) channels are involved in the regulation of
neurotransmitter release and neuronal excitability. Structurally, BK channels are …

Ancillary Subunits Associated With Voltage-Dependent K+ Channels

O Pongs, JR Schwarz - Physiological reviews, 2010 - journals.physiology.org
Since the first discovery of Kvβ-subunits more than 15 years ago, many more ancillary Kv
channel subunits were characterized, for example, KChIPs, KCNEs, and BKβ-subunits. The …

mitoBKCa is encoded by the Kcnma1 gene, and a splicing sequence defines its mitochondrial location

H Singh, R Lu, JC Bopassa… - Proceedings of the …, 2013 - National Acad Sciences
The large-conductance Ca2+-and voltage-activated K+ channel (BKCa, MaxiK), which is
encoded by the Kcnma1 gene, is generally expressed at the plasma membrane of excitable …

Molecular mechanisms of BK channel activation

J Cui, H Yang, US Lee - Cellular and Molecular Life Sciences, 2009 - Springer
Large conductance, Ca 2+-activated potassium (BK) channels are widely expressed
throughout the animal kingdom and play important roles in many physiological processes …

TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology

SE Dryer, J Reiser - American Journal of Physiology-Renal …, 2010 - journals.physiology.org
Loss or dysfunction of podocytes is a major cause of glomerular kidney disease. Several
genetic forms of glomerular disease are caused by mutations in genes that encode structural …

Calcium-and voltage-gated BK channels in vascular smooth muscle

AM Dopico, AN Bukiya, JH Jaggar - Pflügers Archiv-European Journal of …, 2018 - Springer
Ion channels in vascular smooth muscle regulate myogenic tone and vessel contractility. In
particular, activation of calcium-and voltage-gated potassium channels of large conductance …

Regulation of potassium (K) handling in the renal collecting duct

WH Wang, G Giebisch - Pflügers Archiv-European Journal of Physiology, 2009 - Springer
This review provides an overview of the molecular mechanisms of K transport in the
mammalian connecting tubule (CNT) and cortical collecting duct (CCD), both nephron …

Modulation of BKCa Channel Gating by Endogenous Signaling Molecules

S Hou, SH Heinemann, T Hoshi - Physiology, 2009 - journals.physiology.org
Large-conductance Ca2+-and voltage-activated K+ (BKCa, MaxiK, or Slo1) channels are
expressed in almost every tissue in our body and participate in many critical functions such …