During hemolysis, erythrophagocytes dispose damaged red blood cells. This prevents the
extracellular release of hemoglobin, detoxifies heme, and recycles iron in a linked metabolic …

For over 100 years, clinicians and scientists have been unravelling the consequences of the
A to T substitution in the β-globin gene that produces haemoglobin S, which leads to the …

Hemolysis is a pathological feature of several diseases of diverse etiology such as
hereditary anemias, malaria, and sepsis. A major complication of hemolysis involves the …

Background: Plasma proteins are critical mediators of cardiovascular processes and are the
targets of many drugs. Previous efforts to characterize the genetic architecture of the plasma …

Hemolytic diseases are associated with elevated levels of circulating free heme that can
mediate endothelial dysfunction directly via redox reactions with biomolecules or indirectly …

Anthracyclines such as doxorubicin (Dox) are effective chemotherapies, but their use is
limited by cardiac toxicity. We hypothesized that plasma proteomics in women with breast …

The heme oxygenase (HO) system is essential for heme and iron homeostasis and
necessary for adaptation to cell stress. HO degrades heme to biliverdin (BV), carbon …

Sickle cell anemia is a unique disease dominated by hemolytic anemia and vaso-occlusive
events. The latter trigger a version of ischemia/reperfusion (I/R) pathobiology that is singular …

Intravascular hemolysis is a serious complication developed in many severe infections such
as malaria, sepsis, 1 typical hemolytic uremic syndrome2 and congenital diseases such as …

Hemolysis and accumulation of cell-free hemoglobin (Hb) in the circulation or in confined
tissue compartments such as the subarachnoid space is an important driver of disease …