Cadherins mediate cell–cell adhesion through a dynamic process that is strongly dependent
on the cellular context and signaling. Cadherin regulation reflects the interplay between …

Dormancy occurs when cells preserve viability but stop proliferating, which is considered an
important cause of tumor relapse, which may occur many years after clinical remission …

Metastasis is the predominant cause of cancer deaths due to solid organ malignancies;
however, anticancer drugs are not effective in treating metastatic cancer. Here we report a …

Background Sorafenib (SOR) is the first line treatment for advanced hepatocellular
carcinoma (HCC), but resistance develops frequently. Tumor-associated macrophages …

A major cause of cancer recurrence following chemotherapy is cancer dormancy escape.
Taxane-based chemotherapy is standard of care in breast cancer treatment aimed at killing …

Quiescent cancer cells (QCCs) are nonproliferating cells arrested in the G0 phase,
characterized by ki67low and p27high. QCCs avoid most chemotherapies, and some …

Tumor recurrence is a paradoxical function of a machinery, whereby a small proportion of
the cancer cell population enters a resistant, dormant state, persists long-term in this …

We recently showed that a minimally-invasive removal of MDA-MB-231 HM primary tumors
(PTs) and elimination of their secreted factors (including IL-6, IL-8, VEGF, EGF, PDGF-aa …

Progress in detection and treatment have drastically improved survival for early breast
cancer patients. However, distant recurrence causes high mortality and is typically …

Chemotherapy is an effortless and frequently used approach in cancer therapy. However, in
most cases, it can only prolong life expectancy and does not guarantee a complete cure …