Recently accumulating evidence has put into question the role of large multinucleated giant
cells (MNGCs) around bone biomaterials. While cells derived from the monocyte …

Osteoclasts are the bone resorbing cells essential for bone remodeling. Osteoclasts are
formed from hematopoietic progenitors in the monocyte/macrophage lineage …

Osteoclasts are bone-resorbing cells that play a pivotal role in bone remodeling. Osteoclasts
form large multinuclear giant cells by fusion of mononuclear osteoclasts. How cell fusion is …

NFATc1 has been characterized as a master regulator of nuclear factor κB ligand-induced
osteoclast differentiation. Herein, we demonstrate a novel role for NFATc1 as a positive …

CD44, an adhesion molecule that binds to the extracellular matrix, primarily to hyaluronan
(HA), has been implicated in cancer cell migration, invasion, and metastasis. CD44 has also …

Bone has the capacity to alter its mass and structure to its mechanical environment.
Osteocytes are the predominant bone cells and it is generally accepted that the osteocytes …

Bone remodeling involves the interplay of bone resorption and formation and is accurately
controlled to maintain bone mass. Both processes require transcellular Ca2+ transport, but …

The actin cytoskeleton of mature osteoclasts (OCs) adhering to nonmineralized substrates is
organized in a belt of podosomes reminiscent of the sealing zone (SZ) found in bone …

Foreign body multinucleated giant cells (FBGCs) and osteoclasts share several
characteristics, like a common myeloid precursor cell, multinuclearity, expression of tartrate …

The diversity of bone proteoglycan (PG) structure and localisation (pericellular, extracellular
in the organic bone matrix) reflects a broad spectrum of biological functions within a unique …