Abstract Purpose of Review To summarize evidence on the potential involvement of the
osteoprotegerin (OPG)/receptor activator of nuclear factor-kappa B (NF-κΒ) ligand …

Here, we demonstrate that the fractalkine (FKN)/CX3CR1 system represents a regulatory
mechanism for pancreatic islet β cell function and insulin secretion. CX3CR1 knockout (KO) …

The rapidly increasing number of diabetes patients across the world poses a great
challenge to the current therapeutic approach. The traditional method of exogenous supply …

Anaplerosis, the net synthesis in mitochondria of citric acid cycle intermediates, and
cataplerosis, their export to the cytosol, have been shown to be important for insulin …

The ability to detect and target β cells in vivo can substantially refine how diabetes is studied
and treated. However, the lack of specific probes still hampers a precise characterization of …

Abstract Type 2 diabetes (T2D) is characterized by insulin resistance and impaired insulin
secretion, but the mechanisms underlying insulin secretion failure are not completely …

Abstract Aims/hypothesis Endothelial cells (ECs) play an essential role in pancreatic
organogenesis. We hypothesise that effective in vitro interactions between human …

An increased risk of new-onset diabetes mellitus has been recently reported for statin
therapy, and experimental studies have shown reduced glucose-stimulated insulin secretion …

Abstract Background Mesenchymal stromal cells (MSCs) represent an interesting tool to
improve pancreatic islet transplantation. They have immunomodulatory properties and …

In an effort to expand human islets and enhance allogeneic islet transplant for the treatment
of type 1 diabetes, identifying signaling pathways that stimulate human β-cell proliferation is …