Antimicrobial agents play a key role in controlling and curing infectious disease. Soon after
the discovery of the first antibiotic, the challenge of antibiotic resistance commenced …

Importance β-Lactam antibiotics are among the safest and most effective antibiotics. Many
patients report allergies to these drugs that limit their use, resulting in the use of broad …

Background Antimicrobial resistance (AMR) is a serious threat to global public health. WHO
emphasises the need for countries to monitor antibiotic consumption to combat AMR. Many …

Raman optical spectroscopy promises label-free bacterial detection, identification, and
antibiotic susceptibility testing in a single step. However, achieving clinically relevant speeds …

Abstract Background Efforts to prevent Clostridioides difficile infection continue to expand
across the health care spectrum in the United States. Whether these efforts are reducing the …

Researchers have discovered associations between elements of the intestinal microbiome
(including specific microbes, signaling pathways, and microbiota-related metabolites) and …

Background Treating patients with infections due to multidrug-resistant pathogens often
requires substantial healthcare resources. The purpose of this study was to report estimates …

The history of antimicrobial resistance (AMR) evolution and the diversity of the
environmental resistome indicate that AMR is an ancient natural phenomenon. Acquired …

Background The effect of procalcitonin-guided use of antibiotics on treatment for suspected
lower respiratory tract infection is unclear. Methods In 14 US hospitals with high adherence …

Undoubtedly, the discovery of penicillin is one of the greatest milestones in modern
medicine. 2016 marks the 75th anniversary of the first systemic administration of penicillin in …