Fibromyalgia (FM) is a complex syndrome, with an indefinite aetiology and intricate
pathophysiology that affects 2–3% of the world population. From the beginning of the 2000s …

N, N-dimethyltryptamine (DMT) is a potent psychedelic naturally produced by many plants
and animals, including humans. Whether or not DMT is significant to mammalian physiology …

Dexmedetomidine, selective α2-adrenergic agonist dexmedetomidine, has been widely
used clinically for sedation and anesthesia. The role of dexmedetomidine has been an …

Many neurodegenerative diseases are neuropathologically characterized by neuronal loss,
gliosis, and the deposition of misfolded proteins such as β-amyloid (Aβ) plaques and tau …

Repurposing drugs capable of extending lifespan and health span has a huge untapped
potential in translational geroscience. Here, we searched for known compounds that elicit a …

Dexmedetomidine has been increasingly introduced into the perioperative care of surgical
patients. Because a subset of anesthetics/sedatives are immunomodulatory, it is critical to …

Abstract Background Metabolic syndrome (MetS) is a multimorbid long-term condition
without consensual medical definition and a diagnostic based on compatible …

For the past two decades several scholarly reviews have appeared on the inwardly rectifying
potassium (Kir) channels. We would like to highlight two efforts in particular, which have …

Background and Purpose The development of effective therapeutic strategies against
Alzheimer's disease (AD) remains a challenge. I2 imidazoline receptor ligands have a …

Anesthesia-induced neurotoxicity is a set of unfavorable adverse effects on central or
peripheral nervous systems associated with administration of anesthesia. Several animal …