5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

The S100 family of proteins contains 25 known members that share a high degree of
sequence and structural similarity. However, only a limited number of family members have …

Major depressive disorder (MDD) is one of the most disabling psychiatric disorders.
Approximately one‐third of the patients with MDD are treatment resistant to the current …

Major depressive disorder (MDD) will affect one out of every five people in their lifetime and
is the leading cause of disability worldwide. Nevertheless, mechanisms associated with the …

There is increasing interest among functional neurosurgeons in the potential for novel
therapies to impact upon diseases beyond movement disorders and pain. A target of …

Brain development and function depend on the precise regulation of gene expression.
However, our understanding of the complexity and dynamics of the transcriptome of the …

Extensive studies showed that monoaminergic neurotransmission that involves serotonin (5-
HT), norepinephrine (NE) and dopamine (DA) exerts major influence on brain circuits …

Increasing evidence points to an association between major depressive disorders (MDDs)
and diverse types of GABAergic deficits. In this review, we summarize clinical and preclinical …

Unravelling the pathophysiology of depression is a unique challenge. Not only are
depressive syndromes heterogeneous and their aetiologies diverse, but symptoms such as …

Depression occurs in around 35% of patients with Parkinson disease (PD) and is often
persistent. Symptoms of depression can be evident in individuals at the time of diagnosis …