Desmosomes are prominent adhesion sites that are tightly associated with the cytoplasmic
intermediate filament cytoskeleton providing mechanical stability in epithelia and also in …

Desmosomes are intercellular junctions that mediate cell–cell adhesion and anchor the
intermediate filament network to the plasma membrane, providing mechanical resilience to …

Background The microRNA-200 family participates in the maintenance of an epithelial
phenotype and loss of its expression can result in epithelial to mesenchymal transition …

TP53 mutations are found in 5–10% of MDS and AML, where they are generally associated
with complex karyotype and an overall poor prognosis. However, the impact of TP53 …

The epigenetic silencing of tumor suppressor genes is a common event during
carcinogenesis, and often involves aberrant DNA methylation and histone modification of …

p53, known as a tumor suppressor, is a DNA binding protein that regulates cell cycle,
activates DNA repair proteins, and triggers apoptosis in multicellular animals. More than …

miRNAs are important regulators of gene expression that are frequently deregulated in
cancer, with aberrant DNA methylation being an epigenetic mechanism involved in this …

DNA hypomethylation is one of the major epigenetic alterations in human cancers. We have
previously shown that genes identified as hypomethylated in pancreatic cancer are …

Previous studies indicate that estrogen positively regulates lung cancer progression.
Understanding the reasons will be beneficial for treating women with lung cancer in the …

Maspin (mammary serine protease inhibitor), is a member of the serine protease
inhibitor/non-inhibitor superfamily. Its expression is down-regulated in breast, prostate …