It is increasingly acknowledged that a sex and gender specificity affects the occurrence,
development, and consequence of a plethora of pathologies. Mitochondria are considered …

Autoimmune diseases are characterized by circulating antibodies and immune complexes
directed against self-tissues that result in both systemic and organ-specific inflammation and …

The convergence of tissue engineering and patient-specific stem cell biology has enabled
the engineering of in vitro tissue models that allow the study of patient-tailored treatment …

Mitochondria are unique organelles present in almost all cell types. They are involved not
only in the supply of energy to the host cell, but also in multiple biochemical and biological …

Heart failure remains a major public-health problem with an increase in the number of
patients worsening from this disease. Despite current medical therapy, the condition still has …

Ischaemic heart disease (IHD) is a complex disorder and a leading cause of death and
morbidity in both men and women. Sex, however, affects several aspects of IHD, including …

Preserving mitochondrial activity is crucial in rescuing cardiac function following acute
myocardial ischemia/reperfusion (I/R). The sex difference in myocardial functional recovery …

Introduction Clinical studies have shown that low levels of endogenous testosterone are
associated with cardiovascular diseases. Considering the intimate connection between …

Myocardial ischemia has long-lasting negative impacts on cardiomyocyte mitochondrial ATP
production. However, the location (s) of damage to the oxidative phosphorylation pathway …

Cardiac dysfunction/damage following trauma, shock, sepsis, and ischemia impacts clinical
outcomes. Acute inflammation and oxidative stress triggered by these injuries impair …