A variety of cognitive disorders are worsened by stress exposure and involve dysfunction of
the newly evolved prefrontal cortex (PFC). Exposure to acute, uncontrollable stress …

Given the functional interdependencies between the molecular components in a human cell,
a disease is rarely a consequence of an abnormality in a single gene, but reflects the …

Dysregulated neurodevelopment with altered structural and functional connectivity is
believed to underlie many neuropsychiatric disorders, and 'a disease of synapses' is the …

Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved
serine/threonine protein kinase encoded in mammals by two genes that generate two …

Autoimmunity, gastrointestinal (GI) disorders and schizophrenia have been associated with
one another for a long time. This paper reviews these connections and provides a context by …

Astrocytes comprise half of the cells in the brain. Although astrocytes have traditionally been
described as playing a supportive role for neurons, they have recently been recognized as …

Abstract Systems pharmacology is an emerging area of pharmacology which utilizes
network analysis of drug action as one of its approaches. By considering drug actions and …

Recent advances in our understanding of the underlying genetic architecture of psychiatric
disorders has blown away the diagnostic boundaries that are defined by currently used …

Synaptic spines are dynamic structures that regulate neuronal responsiveness and
plasticity. We examined the role of the schizophrenia risk factor DISC1 in the maintenance of …

It is becoming increasingly apparent that spatial regulation of cell signalling processes is
critical to normal cellular function. In this regard, cAMP signalling regulates many pivotal …