During the past decade, an abundance of new evidence highlighted the importance of
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …

PI3Ks regulate several key events in the inflammatory response to damage and infection.
There are four Class I PI3K isoforms (PI3Kα, β, γ, δ), three Class II PI3K isoforms (PI3KC2α …

Highlights•Preclinical studies support us of PI3K inhibitors in autoimmunity and
inflammation.•First in class PI3K inhibitor has been approved for treatment of B cell …

Class I phosphoinositide 3-kinase (PI3K) is a dimeric enzyme, consisting of a catalytic and a
regulatory subunit. The catalytic subunit occurs in four isoforms designated as p110α …

Non-small-cell lung cancer (NSCLC) is the leading cause of cancer deaths worldwide. In the
last years, the identification of activating EGFR mutations, conferring increased sensitivity …

The recent development of a consensus definition and proposed diagnostic criteria for
anaphylaxis offers promise for research efforts and a better understanding of the …

The phosphatidylinositol-3 kinases (PI3Ks) and the mammalian target of rapamycin (mTOR)
pathway have long been recognised as critically regulating metabolism, growth or survival …

The p110 isoforms of phosphoinositide 3-kinase (PI3K) are acutely regulated by
extracellular stimuli. The class IA PI3K catalytic subunits (p110α, p110β, and p110δ) occur in …

We have previously described critical and nonredundant roles for the phosphoinositide 3-
kinase p110δ during the activation and differentiation of naive T cells, and p110δ inhibitors …

Abstract The PI3K/AKT/mTOR pathway regulates cell growth and proliferation and is often
dysregulated in cancer due to mutation, amplification, deletion, methylation and post …