Human lectins are involved in a wide variety of biological processes, both physiological and
pathological, which have attracted the interest of the scientific community working in the …

Carbohydrates (glycans, saccharides, sugars) are everywhere. In fact, glycan–protein
interactions are involved in many essential processes of life and disease. The …

The efficient spread of SARS-CoV-2 resulted in a unique pandemic in modern history.
Despite early identification of ACE2 as the receptor for viral spike protein, much remains to …

Langerhans cells are a subset of dendritic cells residing in the epidermis of the human skin.
As such, they are key mediators of immune regulation and have emerged as prime targets …

Carbohydrates play a pivotal role in intercellular communication processes. In particular,
glycan antigens are key for sustaining homeostasis, helping leukocytes to distinguish …

At the surface of dendritic cells, C-type lectin receptors (CLRs) allow the recognition of
carbohydrate-based PAMPS or DAMPS (pathogen-or danger-associated molecular …

Understanding the dynamics of protein–ligand interactions, which lie at the heart of host–
pathogen recognition, represents a crucial step to clarify the molecular determinants …

Lung surfactant collectins, surfactant protein A (SP-A) and D (SP-D), are oligomeric C-type
lectins involved in lung immunity. Through their carbohydrate recognition domain, they …

Langerin is a C-type lectin present on Langerhans cells that mediates capture of pathogens
in a carbohydrate-dependent manner, leading to subsequent internalization and elimination …

In their role as pattern-recognition receptors on cells of the innate immune system, myeloid
C-type lectin receptors (CLRs) assume important biological functions related to immunity …