High concentration formulation developability approaches and considerations
J Zarzar, T Khan, M Bhagawati, B Weiche… - MAbs, 2023 - Taylor & Francis
The growing need for biologics to be administered subcutaneously and ocularly, coupled
with certain indications requiring high doses, has resulted in an increase in drug substance …
with certain indications requiring high doses, has resulted in an increase in drug substance …
Monoclonal antibody and protein therapeutic formulations for subcutaneous delivery: high-concentration, low-volume vs. low-concentration, high-volume
Biologic drugs are used to treat a variety of cancers and chronic diseases. While most of
these treatments are administered intravenously by trained healthcare professionals, a …
these treatments are administered intravenously by trained healthcare professionals, a …
Terminal supraparticle assemblies from similarly charged protein molecules and nanoparticles
JI Park, TD Nguyen, G de Queirós Silveira… - Nature …, 2014 - nature.com
Self-assembly of proteins and inorganic nanoparticles into terminal assemblies makes
possible a large family of uniformly sized hybrid colloids. These particles can be compared …
possible a large family of uniformly sized hybrid colloids. These particles can be compared …
Frozen-state storage stability of a monoclonal antibody: aggregation is impacted by freezing rate and solute distribution
MA Miller, MA Rodrigues, MA Glass, SK Singh… - Journal of …, 2013 - Elsevier
Freezing of protein solutions perturbs protein conformation, potentially leading to aggregate
formation during long-term storage in the frozen state. Macroscopic protein concentration …
formation during long-term storage in the frozen state. Macroscopic protein concentration …
A cocktail of humanized anti–pertussis toxin antibodies limits disease in murine and baboon models of whooping cough
Despite widespread vaccination, pertussis rates are rising in industrialized countries and
remain high worldwide. With no specific therapeutics to treat disease, pertussis continues to …
remain high worldwide. With no specific therapeutics to treat disease, pertussis continues to …
A novel approach for real-time enumeration of Escherichia coli ATCC 47076 in water through high multi-functional engineered nano-dispersible electrode
The climate change is significantly evolving novel microbes in the environment. In addition,
nanoscience is advancing promptly to provide environmentally friendly engineering …
nanoscience is advancing promptly to provide environmentally friendly engineering …
Viscosity reduction of a concentrated monoclonal antibody with arginine· HCl and arginine· glutamate
AU Borwankar, BJ Dear, A Twu, JJ Hung… - Industrial & …, 2016 - ACS Publications
To further advance a subcutaneous injection of monoclonal antibodies (mAbs) at elevated
concentrations, novel concepts are needed to lower the viscosity. The addition of high …
concentrations, novel concepts are needed to lower the viscosity. The addition of high …
[HTML][HTML] Biopharmaceutical nanoclusters: Towards the self-delivery of protein and peptide therapeutics
Protein and peptide biopharmaceuticals have had a major impact on the treatment of a
number of diseases. There is a growing interest in overcoming some of the challenges …
number of diseases. There is a growing interest in overcoming some of the challenges …
Dual Responsive Disposable Electrode for the Enumeration of Escherichia coli in Whole Blood
In this report, we have designed a dual responsive disposable electrode for the enumeration
of Escherichia coli K12 (E. coli K12). The immunomagnetic separation strategy provided …
of Escherichia coli K12 (E. coli K12). The immunomagnetic separation strategy provided …
High-throughput analysis of sub-visible mAb aggregate particles using automated fluorescence microscopy imaging
AJ Paul, F Bickel, M Röhm, L Hospach… - Analytical and …, 2017 - Springer
Aggregation of therapeutic proteins is a major concern as aggregates lower the yield and
can impact the efficacy of the drug as well as the patient's safety. It can occur in all …
can impact the efficacy of the drug as well as the patient's safety. It can occur in all …