Examining horizontal gene transfer in microbial communities

IL Brito - Nature Reviews Microbiology, 2021 - nature.com
Bacteria acquire novel DNA through horizontal gene transfer (HGT), a process that enables
an organism to rapidly adapt to changing environmental conditions, provides a competitive …

Piercing the dark matter: bioinformatics of long-range sequencing and mapping

FJ Sedlazeck, H Lee, CA Darby, MC Schatz - Nature Reviews Genetics, 2018 - nature.com
Several new genomics technologies have become available that offer long-read sequencing
or long-range mapping with higher throughput and higher resolution analysis than ever …

Generating lineage-resolved, complete metagenome-assembled genomes from complex microbial communities

DM Bickhart, M Kolmogorov, E Tseng, DM Portik… - Nature …, 2022 - nature.com
Microbial communities might include distinct lineages of closely related organisms that
complicate metagenomic assembly and prevent the generation of complete metagenome …

Assembly of 913 microbial genomes from metagenomic sequencing of the cow rumen

RD Stewart, MD Auffret, A Warr, AH Wiser… - Nature …, 2018 - nature.com
The cow rumen is adapted for the breakdown of plant material into energy and nutrients, a
task largely performed by enzymes encoded by the rumen microbiome. Here we present …

Good microbes, bad genes? The dissemination of antimicrobial resistance in the human microbiome

A Crits-Christoph, HA Hallowell, K Koutouvalis… - Gut …, 2022 - Taylor & Francis
ABSTRACT A global rise in antimicrobial resistance among pathogenic bacteria has proved
to be a major public health threat, with the rate of multidrug-resistant bacterial infections …

Evaluating the information content of shallow shotgun metagenomics

B Hillmann, GA Al-Ghalith, RR Shields-Cutler, Q Zhu… - Msystems, 2018 - Am Soc Microbiol
Although microbial communities are associated with human, environmental, plant, and
animal health, there exists no cost-effective method for precisely characterizing species and …

Discovering multiple types of DNA methylation from bacteria and microbiome using nanopore sequencing

A Tourancheau, EA Mead, XS Zhang, G Fang - Nature methods, 2021 - nature.com
Bacterial DNA methylation occurs at diverse sequence contexts and plays important
functional roles in cellular defense and gene regulation. Existing methods for detecting DNA …

Antimicrobial peptides: from design to clinical application

C Zhang, M Yang - Antibiotics, 2022 - mdpi.com
Infection of multidrug-resistant (MDR) bacteria, such as methicillin-resistant Staphylococcus
aureus (MRSA), carbapenem-resistant Enterobacteriaceae (CRE), and extended-spectrum …

Genome-wide mapping and analysis of chromosome architecture

AD Schmitt, M Hu, B Ren - Nature reviews Molecular cell biology, 2016 - nature.com
Chromosomes of eukaryotes adopt highly dynamic and complex hierarchical structures in
the nucleus. The three-dimensional (3D) organization of chromosomes profoundly affects …

Computational approaches to predict bacteriophage–host relationships

RA Edwards, K McNair, K Faust, J Raes… - FEMS microbiology …, 2016 - academic.oup.com
Metagenomics has changed the face of virus discovery by enabling the accurate
identification of viral genome sequences without requiring isolation of the viruses. As a …