Cells on chips

J El-Ali, PK Sorger, KF Jensen - Nature, 2006 - nature.com
Microsystems create new opportunities for the spatial and temporal control of cell growth
and stimuli by combining surfaces that mimic complex biochemistries and geometries of the …

Microfluidic devices for bioapplications

LY Yeo, HC Chang, PPY Chan, JR Friend - small, 2011 - Wiley Online Library
Harnessing the ability to precisely and reproducibly actuate fluids and manipulate
bioparticles such as DNA, cells, and molecules at the microscale, microfluidics is a powerful …

Integrating biosensors in organs-on-chip devices: A perspective on current strategies to monitor microphysiological systems

E Ferrari, C Palma, S Vesentini, P Occhetta, M Rasponi - Biosensors, 2020 - mdpi.com
Organs-on-chip (OoC), often referred to as microphysiological systems (MPS), are advanced
in vitro tools able to replicate essential functions of human organs. Owing to their …

3D in vitro modeling of the central nervous system

AM Hopkins, E DeSimone, K Chwalek… - Progress in …, 2015 - Elsevier
There are currently more than 600 diseases characterized as affecting the central nervous
system (CNS) which inflict neural damage. Unfortunately, few of these conditions have …

Microfluidics for neuronal cell and circuit engineering

R Habibey, JE Rojo Arias, J Striebel… - Chemical …, 2022 - ACS Publications
The widespread adoption of microfluidic devices among the neuroscience and neurobiology
communities has enabled addressing a broad range of questions at the molecular, cellular …

Microfabricated mammalian organ systems and their integration into models of whole animals and humans

JH Sung, MB Esch, JM Prot, CJ Long, A Smith… - Lab on a Chip, 2013 - pubs.rsc.org
While in vitro cell based systems have been an invaluable tool in biology, they often suffer
from a lack of physiological relevance. The discrepancy between the in vitro and in vivo …

Digital microfluidics for cell-based assays

I Barbulovic-Nad, H Yang, PS Park, AR Wheeler - Lab on a Chip, 2008 - pubs.rsc.org
We introduce a new method for implementing cell-based assays. The method is based on
digital microfluidics (DMF) which is used to actuate nanolitre droplets of reagents and cells …

Will microfluidics enable functionally integrated biohybrid robots?

M Filippi, O Yasa, RD Kamm… - Proceedings of the …, 2022 - National Acad Sciences
The next robotics frontier will be led by biohybrids. Capable biohybrid robots require
microfluidics to sustain, improve, and scale the architectural complexity of their core …

Functional characterization of human pluripotent stem cell-derived models of the brain with microelectrode arrays

A Pelkonen, C Pistono, P Klecki, M Gómez-Budia… - Cells, 2021 - mdpi.com
Human pluripotent stem cell (hPSC)-derived neuron cultures have emerged as models of
electrical activity in the human brain. Microelectrode arrays (MEAs) measure changes in the …

Microfluidic compartmentalized co-culture platform for CNS axon myelination research

J Park, H Koito, J Li, A Han - Biomedical microdevices, 2009 - Springer
This paper presents a circular microfluidic compartmentalized co-culture platform that can be
used for central nervous system (CNS) axon myelination research. The microfluidic platform …