N, N-Dimethylformamide (DMF) is frequently used as an aprotic solvent in chemical
transformations in laboratories of academia as well as in those of chemical industry. In the …

The reduction of amides gives access to a wide variety of important compounds such as
amines, imines, enamines, nitriles, aldehydes and alcohols. The chemoselective …

The nucleophilic addition of carbon nucleophiles to amides has traditionally been a difficult
task, both due to reactivity and selectivity problems. When successful, these processes …

A variety of inert tertiary amides have been successfully transformed into synthetically
important chiral propargylamines in high yields with good to excellent enantioselectivities …

The combination of transition‐metal catalysis and organocatalysis increasingly offers
chemists opportunities to realize diverse unprecedented chemical transformations. By …

Amines are an important class of compounds that constitute the major body of bioactive
natural products (alkaloids) and pharmaceuticals.[1] Amides are a class of easily available …

A unified total synthesis of stemoamide-type alkaloids is reported. Our synthetic approach
features the chemoselective convergent assembly of five-membered building blocks via …

The partial reduction of amides is a challenging transformation that must overcome the
intrinsic stability of the amide bond and exhibit high chemoselective control to avoid …

Amides are a class of easily available compounds, and widely serve as versatile
intermediates in organic synthesis and medicinal chemistry. Amide-based transformations …

Nucleophilic addition to amides has been recognized as a promising transformation for total
synthesis of complex alkaloids. Amides can accept two different organometallic reagents …