Extrachromosomal DNA (ecDNA) amplification is an important driver alteration in cancer. It
has been observed in most cancer types and is associated with worse patient outcome. The …

Extrachromosomal circular DNA (eccDNA) is a double-stranded DNA molecule found in
various organisms, including humans. In the past few decades, the research on eccDNA has …

Extrachromosomal circular DNA (eccDNA) is common in somatic tissue, but its existence
and effects in the human germline are unexplored. We used microscopy, long-read DNA …

High grade serous ovarian cancer (HGSOC) is the most aggressive subtype of ovarian
cancer and HGSOC patients often appear with metastasis, leading to the poor prognosis. Up …

Background Extrachromosomal circular deoxyribonucleic acid (eccDNA) is evolving as a
valuable biomarker, while little is known about its presence in urine. Methods Here, we …

Abiotic stresses are responsible for the major losses in crop yield all over the world. Stresses
generate harmful ROS which can impair cellular processes in plants. Therefore, plants have …

Extrachromosomal circular DNA (eccDNA) is a type of double-stranded circular DNA that is
derived and free from chromosomes. It has a strong heterogeneity in sequence, length, and …

Extrachromosomal circular DNA (eccDNA) has been observed in different species for
decades, and more and more evidence shows that this specific type of DNA molecules may …

Extrachromosomal circular DNA was recently found to be particularly abundant in multiple
human cancer cells, although its frequency varies among different tumor types. Elevated …

The dynamic three-dimensional structures of chromatin and extrachromosomal DNA
molecules regulate fundamental cellular processes and beyond. However, the visualization …