In vertebrates and invertebrates, biomineralization is controlled by the cell and the proteins
they produce. A large number of these proteins are intrinsically disordered, gaining some …

X-linked hypophosphatemia (XLH) is the most common genetic form of hypophosphatemic
rickets and osteomalacia. In this disease, mutations in the PHEX gene lead to elevated …

Amelogenesis imperfecta (AI) is a heterogeneous group of genetic rare diseases disrupting
enamel development (Smith et al., Front Physiol, 2017a, 8, 333). The clinical enamel …

Background Orodental diseases include several clinically and genetically heterogeneous
disorders that can present in isolation or as part of a genetic syndrome. Due to the vast …

The study of extracellular phosphorylation was initiated in late 19th century when the
secreted milk protein, casein, and egg-yolk protein, phosvitin, were shown to be …

FAM20C is a gene coding for a protein kinase that targets SXE/pS motifs on different
phosphoproteins belonging to diverse tissues. Pathogenic variants of FAM20C are …

Dental mesenchymal stem cells (DMSCs) are multipotent progenitor cells that can
differentiate into multiple lineages including odontoblasts, osteoblasts, chondrocytes, neural …

Introduction The aim of this systematic review (Prospero CRD42022323188) is to investigate
whether an association exists in patients with amelogenesis imperfecta (AI) between …

Background Amelogenesis imperfecta (AI) is a group of genetic diseases characterised by
tooth enamel defects. AI was recently described in patients with familial hypercalciuria and …

ABSTRACT X‐linked hypophosphatemia (XLH), a dominant disorder caused by pathogenic
variants in the PHEX gene, affects both sexes of all ages and results in elevated serum …