A toxic shrub turned therapeutic: The dichotomy of Nerium oleander bioactivities

R Sharma, S Singh, N Tewari, P Dey - Toxicon, 2023 - Elsevier
Nerium oleander L. is a medicinal plant, used for the treatment of cancers and
hyperglycemia across the world, especially in Indian sub-continent, Turkey, Morocco, and …

[HTML][HTML] Oleandrin: A cardiac glycosides with potent cytotoxicity

A Kumar, T De, A Mishra, AK Mishra - Pharmacognosy reviews, 2013 - ncbi.nlm.nih.gov
Cardiac glycosides are used in the treatment of congestive heart failure and arrhythmia.
Current trend shows use of some cardiac glycosides in the treatment of proliferative …

Green synthesis of Nerium oleander-conjugated gold nanoparticles and study of its in vitro anticancer activity on MCF-7 cell lines and catalytic activity

AC Barai, K Paul, A Dey, S Manna, S Roy, BG Bag… - Nano convergence, 2018 - Springer
The phytochemicals present in the stem bark extract of Nerium oleander (commonly known
as Karabi) have been utilized for the green synthesis of stable gold-conjugated …

Molecular Modes of Action of an Aqueous Nerium oleander Extract in Cancer Cells In Vitro and In Vivo

LJ Rashan, N Özenver, JC Boulos, M Dawood… - Molecules, 2023 - mdpi.com
Cancer drug resistance remains a major obstacle in clinical oncology. As most anticancer
drugs are of natural origin, we investigated the anticancer potential of a standardized cold …

[PDF][PDF] Bioactive ingredients and pharmacological effects of Nerium oleander

AE Al-Snafi - IOSR Journal of Pharmacy, 2020 - researchgate.net
The phytochemical screening showed that of Nerium oleander contained alkaloids,
flavonoids, carbohydrates, tannins, phenolics, saponins, cardenolides, cardiac glycosides …

Oleandrin-mediated inhibition of human tumor cell proliferation: Importance of Na, K-ATPase α subunits as drug targets

P Yang, DG Menter, C Cartwright, D Chan… - Molecular cancer …, 2009 - AACR
Cardiac glycosides such as oleandrin are known to inhibit the Na, K-ATPase pump, resulting
in a consequent increase in calcium influx in heart muscle. Here, we investigated the effect …

[HTML][HTML] Antiproliferative and phytochemical analyses of leaf extracts of ten Apocynaceae species

SK Wong, YY Lim, NR Abdullah… - Pharmacognosy …, 2011 - ncbi.nlm.nih.gov
Background: The anticancer properties of Apocynaceae species are well known in barks
and roots but less so in leaves. Materials and Methods: In this study, leaf extracts of 10 …

[HTML][HTML] The pharmaco-toxicological conundrum of oleander: potential role of gut microbiome

P Dey - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Nerium oleander L., commonly known as oleander, is a toxic shrub and also a medicinal
plant. All parts of oleander are rich in cardiac glycosides that inhibits Na+/K+-ATPase and …

PBI-05204, a supercritical CO2 extract of Nerium oleander, inhibits growth of human pancreatic cancer via targeting the PI3K/mTOR pathway

Y Pan, P Rhea, L Tan, C Cartwright, HJ Lee… - Investigational New …, 2015 - Springer
Introduction Oleandrin, a cardiac glycoside, exerts strong anti-proliferative activity against
various human malignancies in in vitro cells. Here, we report the antitumor efficacy of PBI …

[HTML][HTML] Pharmacological aspects of Nerium indicum Mill: a comprehensive review

P Dey, TK Chaudhuri - Pharmacognosy reviews, 2014 - ncbi.nlm.nih.gov
Phytomedicine is the oldest medical practice known to man. Since the dawn of mankind,
various plant resources are used to cure different diseases and also for a long and healthy …