Exosome-based immunotherapy: a promising approach for cancer treatment

Z Xu, S Zeng, Z Gong, Y Yan - Molecular cancer, 2020 - Springer
In the era of the rapid development of cancer immunotherapy, there is a high level of interest
in the application of cell-released small vesicles that stimulate the immune system. As cell …

The tumor microenvironment: a milieu hindering and obstructing antitumor immune responses

A Labani-Motlagh, M Ashja-Mahdavi… - Frontiers in …, 2020 - frontiersin.org
The success of cancer immunotherapy relies on the knowledge of the tumor
microenvironment and the immune evasion mechanisms in which the tumor, stroma, and …

Engineered neutrophil-derived exosome-like vesicles for targeted cancer therapy

J Zhang, C Ji, H Zhang, H Shi, F Mao, H Qian, W Xu… - Science …, 2022 - science.org
Neutrophils are the most abundant innate immune cells in human circulation; however, their
derived exosomes have been rarely studied for tumor treatment. Here, we reported that …

Engineered extracellular vesicles for cancer therapy

X Zhang, H Zhang, J Gu, J Zhang, H Shi… - Advanced …, 2021 - Wiley Online Library
Extracellular vesicles (EVs) have emerged as a novel cell‐free strategy for the treatment of
many diseases including cancer. As a result of their natural properties to mediate cell‐to‐cell …

Engineered extracellular vesicles and their mimetics for cancer immunotherapy

C Liu, Y Wang, L Li, D He, J Chi, Q Li, Y Wu… - Journal of Controlled …, 2022 - Elsevier
Extracellular vesicles (EVs) are heterogeneous membranous vesicles secreted by living
cells that are involved in many physiological and pathological processes as intermediaries …

Emerging prospects of exosomes for cancer treatment: from conventional therapy to immunotherapy

GH Nam, Y Choi, GB Kim, S Kim, SA Kim… - Advanced …, 2020 - Wiley Online Library
Exosomes are a class of extracellular vesicles of around 100 nm in diameter that are
secreted by most cells and contain various bioactive molecules reflecting their cellular origin …

CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity

W Fu, C Lei, S Liu, Y Cui, C Wang, K Qian, T Li… - Nature …, 2019 - nature.com
Genetically engineered T cells expressing a chimeric antigen receptor (CAR) are rapidly
emerging a promising new treatment for haematological and non-haematological …

[HTML][HTML] Cancer immunotherapy based on natural killer cells: current progress and new opportunities

W Hu, G Wang, D Huang, M Sui, Y Xu - Frontiers in immunology, 2019 - frontiersin.org
Cancer immunotherapy has been firmly established as a new milestone for cancer therapy,
with the development of multiple immune cells as therapeutic tools. Natural killer (NK) cells …

The molecular mechanism of natural killer cells function and its importance in cancer immunotherapy

S Paul, G Lal - Frontiers in immunology, 2017 - frontiersin.org
Natural killer (NK) cells are innate immune cells that show strong cytolytic function against
physiologically stressed cells such as tumor cells and virus-infected cells. NK cells show a …

Biodistribution of exosomes and engineering strategies for targeted delivery of therapeutic exosomes

H Choi, Y Choi, HY Yim, A Mirzaaghasi, JK Yoo… - Tissue engineering and …, 2021 - Springer
Exosomes are cell-secreted nano-sized vesicles which deliver diverse biological molecules
for intercellular communication. Due to their therapeutic potential, exosomes have been …