Despite a strong preclinical rationale for targeting the insulin-like growth factor (IGF) axis in
cancer, clinical studies of IGF-1 receptor (IGF-1R)-targeted monotherapies have been …

Numerous epidemiological and pre-clinical studies have demonstrated that the
insulin/insulin-like growth factor (IGF) system plays a key role in the development and …

Introduction: Many patients with oncogene-driven non–small-cell lung cancer (NSCLC)
treated with tyrosine kinase inhibitors experience limited sites of disease progression. This …

We report a surface-enhanced Raman scattering (SERS)-based cellular imaging technique
to detect and quantify breast cancer phenotypic markers expressed on cell surfaces. This …

Introduction: Over the past decade, several library-based methods have been developed to
discover ligands with strong binding affinities for their targets. These methods mimic the …

IGF-1R inhibitors arrived in the clinic accompanied by optimism based on preclinical activity
of IGF-1R targeting, and recognition that low IGF bioactivity protects from cancer. This was …

The application of repertoire selection technologies for the study and characterization of
tumor heterogeneity is an area of great interest in the field of tumor biology and …

Lung cancer first line treatment has been directed from the non-specific cytotoxic doublet
chemotherapy to the molecular targeted. The major limitation of the targeted therapies still …

During the past 20 years, dozens—if not hundreds—of monoclonal antibodies have been
developed and characterized for their capacity to mediate antineoplastic effects, either as …

Recent advances in genomic sequencing and omics-based capabilities are uncovering
tremendous therapeutic opportunities and rapidly transforming the field of cancer medicine …