Insulin-like growth factor (IGF) pathway targeting in cancer: role of the IGF axis and opportunities for future combination studies
A Simpson, W Petnga, VM Macaulay… - Targeted …, 2017 - Springer
Despite a strong preclinical rationale for targeting the insulin-like growth factor (IGF) axis in
cancer, clinical studies of IGF-1 receptor (IGF-1R)-targeted monotherapies have been …
cancer, clinical studies of IGF-1 receptor (IGF-1R)-targeted monotherapies have been …
The role of the insulin/IGF system in cancer: lessons learned from clinical trials and the energy balance-cancer link
LW Bowers, EL Rossi, CH O'Flanagan… - Frontiers in …, 2015 - frontiersin.org
Numerous epidemiological and pre-clinical studies have demonstrated that the
insulin/insulin-like growth factor (IGF) system plays a key role in the development and …
insulin/insulin-like growth factor (IGF) system plays a key role in the development and …
[HTML][HTML] Local ablative therapy of oligoprogressive disease prolongs disease control by tyrosine kinase inhibitors in oncogene-addicted non–small-cell lung cancer
AJ Weickhardt, B Scheier, JM Burke, G Gan… - Journal of Thoracic …, 2012 - Elsevier
Introduction: Many patients with oncogene-driven non–small-cell lung cancer (NSCLC)
treated with tyrosine kinase inhibitors experience limited sites of disease progression. This …
treated with tyrosine kinase inhibitors experience limited sites of disease progression. This …
Rapid and sensitive phenotypic marker detection on breast cancer cells using surface-enhanced Raman scattering (SERS) imaging
S Lee, H Chon, J Lee, J Ko, BH Chung, DW Lim… - Biosensors and …, 2014 - Elsevier
We report a surface-enhanced Raman scattering (SERS)-based cellular imaging technique
to detect and quantify breast cancer phenotypic markers expressed on cell surfaces. This …
to detect and quantify breast cancer phenotypic markers expressed on cell surfaces. This …
Advances in phage display technology for drug discovery
K Omidfar, M Daneshpour - Expert opinion on drug discovery, 2015 - Taylor & Francis
Introduction: Over the past decade, several library-based methods have been developed to
discover ligands with strong binding affinities for their targets. These methods mimic the …
discover ligands with strong binding affinities for their targets. These methods mimic the …
Can we unlock the potential of IGF-1R inhibition in cancer therapy?
H King, T Aleksic, P Haluska, VM Macaulay - Cancer treatment reviews, 2014 - Elsevier
IGF-1R inhibitors arrived in the clinic accompanied by optimism based on preclinical activity
of IGF-1R targeting, and recognition that low IGF bioactivity protects from cancer. This was …
of IGF-1R targeting, and recognition that low IGF bioactivity protects from cancer. This was …
Phage display libraries: from binders to targeted drug delivery and human therapeutics
M Sioud - Molecular biotechnology, 2019 - Springer
The application of repertoire selection technologies for the study and characterization of
tumor heterogeneity is an area of great interest in the field of tumor biology and …
tumor heterogeneity is an area of great interest in the field of tumor biology and …
[HTML][HTML] Molecular targeted drugs and biomarkers in NSCLC, the evolving role of individualized therapy
K Domvri, P Zarogoulidis, K Darwiche… - Journal of …, 2013 - ncbi.nlm.nih.gov
Lung cancer first line treatment has been directed from the non-specific cytotoxic doublet
chemotherapy to the molecular targeted. The major limitation of the targeted therapies still …
chemotherapy to the molecular targeted. The major limitation of the targeted therapies still …
Trial watch: Monoclonal antibodies in cancer therapy
E Vacchelli, A Eggermont, J Galon… - …, 2013 - Taylor & Francis
During the past 20 years, dozens—if not hundreds—of monoclonal antibodies have been
developed and characterized for their capacity to mediate antineoplastic effects, either as …
developed and characterized for their capacity to mediate antineoplastic effects, either as …
Approaches to modernize the combination drug development paradigm
D Day, LL Siu - Genome medicine, 2016 - Springer
Recent advances in genomic sequencing and omics-based capabilities are uncovering
tremendous therapeutic opportunities and rapidly transforming the field of cancer medicine …
tremendous therapeutic opportunities and rapidly transforming the field of cancer medicine …