[HTML][HTML] Proactive and reactive roles of TGF-β in EMT-induced plasticity
Cancer cells adapt to varying stress conditions to survive through plasticity. Stem cells
exhibit a high degree of plasticity, allowing them to generate more stem cells or differentiate …
exhibit a high degree of plasticity, allowing them to generate more stem cells or differentiate …
[HTML][HTML] Inside the stemness engine: Mechanistic links between deregulated transcription factors and stemness in cancer
EH Ervin, R French, CH Chang, S Pauklin - Seminars in cancer biology, 2022 - Elsevier
Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …
Oncogenic drivers and therapeutic vulnerabilities in KRAS wild-type pancreatic cancer
Abstract Purpose: Approximately 8% to 10% of pancreatic ductal adenocarcinomas (PDAC)
do not harbor mutations in KRAS. Understanding the unique molecular and clinical features …
do not harbor mutations in KRAS. Understanding the unique molecular and clinical features …
TGFβ signaling in the pancreatic tumor microenvironment
DR Principe, KE Timbers, LG Atia, RM Koch, A Rana - Cancers, 2021 - mdpi.com
Simple Summary There is currently no effective treatment for patients with advanced
pancreatic ductal adenocarcinoma (PDAC). Transforming Growth Factor β (TGFβ) signaling …
pancreatic ductal adenocarcinoma (PDAC). Transforming Growth Factor β (TGFβ) signaling …
Epigenetic control of pancreatic cancer metastasis
L Krauß, C Schneider, E Hessmann, D Saur… - Cancer and Metastasis …, 2023 - Springer
Surgical resection, when combined with chemotherapy, has been shown to significantly
improve the survival rate of patients with pancreatic ductal adenocarcinoma (PDAC) …
improve the survival rate of patients with pancreatic ductal adenocarcinoma (PDAC) …
The Fra-1/AP-1 oncoprotein: from the “Undruggable” transcription factor to therapeutic targeting
Simple Summary Cancer-associated mortality largely depends on metastatic dissemination.
Metastasizing cancer cells exhibit drastic phenotypic changes, including the ability to …
Metastasizing cancer cells exhibit drastic phenotypic changes, including the ability to …
Overexpression of FRA1 (FOSL1) Leads to Global Transcriptional Perturbations, Reduced Cellular Adhesion and Altered Cell Cycle Progression
W Al-Khayyat, J Pirkkanen, J Dougherty, T Laframboise… - Cells, 2023 - mdpi.com
FRA1 (FOSL1) is a transcription factor and a member of the activator protein-1 superfamily.
FRA1 is expressed in most tissues at low levels, and its expression is robustly induced in …
FRA1 is expressed in most tissues at low levels, and its expression is robustly induced in …
SMAD proteins in TGF-β signalling pathway in cancer: regulatory mechanisms and clinical applications
Q Wang, F Xiong, G Wu, D Wang, W Liu, J Chen, Y Qi… - Diagnostics, 2023 - mdpi.com
Suppressor of mother against decapentaplegic (SMAD) family proteins are central to one of
the most versatile cytokine signalling pathways in metazoan biology, the transforming …
the most versatile cytokine signalling pathways in metazoan biology, the transforming …
Exosome-transmitted FOSL1 from cancer-associated fibroblasts drives colorectal cancer stemness and chemo-resistance through transcriptionally activating ITGB4
S Lin, B Zhu - Molecular and cellular biochemistry, 2024 - Springer
Cancer-associated fibroblasts (CAFs) have been proved to facilitate colorectal cancer (CRC)
development, either with boosting chemo-resistance by communicating with CRC cells in …
development, either with boosting chemo-resistance by communicating with CRC cells in …
Melatonin inhibits the stemness of head and neck squamous cell carcinoma by modulating HA synthesis via the FOSL1/HAS3 axis
X Luo, J Wang, Y Chen, X Zhou, Z Shao… - Journal of Pineal …, 2024 - Wiley Online Library
Hyaluronic acid (HA) is a glycosaminoglycan and the main component of the extracellular
matrix (ECM), which has been reported to interact with its receptor CD44 to play critical roles …
matrix (ECM), which has been reported to interact with its receptor CD44 to play critical roles …