Cancer cells adapt to varying stress conditions to survive through plasticity. Stem cells
exhibit a high degree of plasticity, allowing them to generate more stem cells or differentiate …

Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …

Abstract Purpose: Approximately 8% to 10% of pancreatic ductal adenocarcinomas (PDAC)
do not harbor mutations in KRAS. Understanding the unique molecular and clinical features …

Simple Summary There is currently no effective treatment for patients with advanced
pancreatic ductal adenocarcinoma (PDAC). Transforming Growth Factor β (TGFβ) signaling …

Surgical resection, when combined with chemotherapy, has been shown to significantly
improve the survival rate of patients with pancreatic ductal adenocarcinoma (PDAC) …

Simple Summary Cancer-associated mortality largely depends on metastatic dissemination.
Metastasizing cancer cells exhibit drastic phenotypic changes, including the ability to …

FRA1 (FOSL1) is a transcription factor and a member of the activator protein-1 superfamily.
FRA1 is expressed in most tissues at low levels, and its expression is robustly induced in …

Suppressor of mother against decapentaplegic (SMAD) family proteins are central to one of
the most versatile cytokine signalling pathways in metazoan biology, the transforming …

Cancer-associated fibroblasts (CAFs) have been proved to facilitate colorectal cancer (CRC)
development, either with boosting chemo-resistance by communicating with CRC cells in …

Hyaluronic acid (HA) is a glycosaminoglycan and the main component of the extracellular
matrix (ECM), which has been reported to interact with its receptor CD44 to play critical roles …