How the kidney is impacted by the perinatal maternal environment to develop hypertension
AD Paixão, BT Alexander - Biology of reproduction, 2013 - academic.oup.com
Environmental conditions during perinatal development such as maternal undernutrition,
maternal glucocorticoids, placental insufficiency, and maternal sodium overload can …
maternal glucocorticoids, placental insufficiency, and maternal sodium overload can …
The second sodium pump: from the function to the gene
MA Rocafull, LE Thomas, JR Del Castillo - Pflügers Archiv-European …, 2012 - Springer
Transepithelial Na+ transport is mediated by passive Na+ entry across the luminal
membrane and exit through the basolateral membrane by two active mechanisms: the …
membrane and exit through the basolateral membrane by two active mechanisms: the …
[HTML][HTML] Protective outcomes of low-dose doxycycline on renal function of Wistar rats subjected to acute ischemia/reperfusion injury
AL Cortes, SR Gonsalez, LS Rioja, SSC Oliveira… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Renal ischemia-reperfusion injury (IRI) is a major cause of acute renal failure. Doxycycline
(Dc) belongs to the tetracycline-class of antibiotics with demonstrated beneficial molecular …
(Dc) belongs to the tetracycline-class of antibiotics with demonstrated beneficial molecular …
O-GlcNAcylation reduces proximal tubule protein reabsorption and promotes proteinuria in spontaneously hypertensive rats
RP Silva-Aguiar, NCF Bezerra, MC Lucena… - Journal of Biological …, 2018 - ASBMB
Hypertensive individuals are at greater risk for developing chronic kidney disease (CKD).
Reducing proteinuria has been suggested as a possible therapeutic approach to treat CKD …
Reducing proteinuria has been suggested as a possible therapeutic approach to treat CKD …
Exposure to low dose of Bisphenol A (BPA) intensifies kidney oxidative stress, inflammatory factors expression and modulates Angiotensin II signaling under …
M Nagarajan, GB Maadurshni… - Journal of Biochemical …, 2024 - Wiley Online Library
Humans are constantly exposed to low concentrations of ubiquitous environmental pollutant,
Bisphenol A (BPA). Due to the prevalence of hypertension (one of the major risk factors of …
Bisphenol A (BPA). Due to the prevalence of hypertension (one of the major risk factors of …
[HTML][HTML] A high salt diet induces tubular damage associated with a pro-inflammatory and pro-fibrotic response in a hypertension-independent manner
DE Teixeira, DB Peruchetti, MC Souza… - … et Biophysica Acta (BBA …, 2020 - Elsevier
High salt diet (HSD), considered a public health problem worldwide, is associated with
chronic degenerative diseases including renal diseases. However, little is known about the …
chronic degenerative diseases including renal diseases. However, little is known about the …
Transplantation of bone marrow-derived MSCs improves renal function and Na++K+-ATPase activity in rats with renovascular hypertension
Renovascular hypertension (RVH) is a progressive disease, leading to chronic kidney
disease when untreated and no specific treatment is available. Therefore, development of …
disease when untreated and no specific treatment is available. Therefore, development of …
Renal molecular mechanisms underlying altered Na+ handling and genesis of hypertension during adulthood in prenatally undernourished rats
LD Vieira-Filho, EV Cabral, JS Farias… - British journal of …, 2014 - cambridge.org
In the present study, we investigated the development of hypertension in prenatally
undernourished adult rats, including the mechanisms that culminate in dysfunctions of …
undernourished adult rats, including the mechanisms that culminate in dysfunctions of …
Changes in angiotensin receptors expression play a pivotal role in the renal damage observed in spontaneously hypertensive rats
SS Landgraf, M Wengert, JS Silva… - American Journal …, 2011 - journals.physiology.org
The renal renin-angiotensin system plays a central role in the development of hypertension.
The aim of this work was to verify the expression of angiotensin II receptors AT1R and AT2R …
The aim of this work was to verify the expression of angiotensin II receptors AT1R and AT2R …
ANG-(3–4) inhibits renal Na+-ATPase in hypertensive rats through a mechanism that involves dissociation of ANG II receptors, heterodimers, and PKA
J Dias, FM Ferrão, F Axelband… - American Journal …, 2014 - journals.physiology.org
The physiological roles of ANG-(3–4)(Val-Tyr), a potent ANG II-derived peptide, remain
largely unknown. The present study 1) investigates whether ANG-(3–4) modulates ouabain …
largely unknown. The present study 1) investigates whether ANG-(3–4) modulates ouabain …