Conspectus Enzymes are essential for life, especially in the development of disease and on
drug effects, but as we cannot yet directly observe the inside interactions and only partially …

The molecular imaging of apoptosis remains an important method for the diagnosis and
monitoring of the progression of certain diseases and the evaluation of the efficacy of …

Small molecules are powerful tools for investigating protein function and can serve as leads
for new therapeutics. Most human proteins, however, lack small-molecule ligands, and …

Platinum (IV) prodrugs c, c, t-[PtCl 2 (NH 3) 2 (OH)(amlexanox)](MAP) and c, c, t-[PtCl 2 (NH
3) 2 (amlexanox) 2](DAP) were synthesized by reacting amlexanox with oxoplatin and …

Caspases are a highly conserved family of cysteine-aspartyl proteases known for their
essential roles in regulating apoptosis, inflammation, cell differentiation, and proliferation …

Caspases are proteases of clan CD and were described for the first time more than two
decades ago. They play critical roles in the control of regulated cell death pathways …

In this article, a series of novel quinoline derivatives of ursolic acid (UA) bearing hydrazide,
oxadiazole, or thiadiazole moieties were designed, synthesised, and screened for their in …

Due to hurdles, including resistance, adverse effects, and poor bioavailability, among others
linked with existing therapies, there is an urgent unmet need to devise new, safe, and more …

As a result of their high specificity for their corresponding biological targets, peptides have
shown significant potential in a range of diagnostic and therapeutic applications. However …

Proteases are enzymes that hydrolyze the peptide bond of peptide substrates and proteins.
Despite significant progress in recent years, one of the greatest challenges in the design …